Movement of a novel serum tumour marker, RCAS1, in patients with biliary diseases
Movement of a novel serum tumour marker, RCAS1, in patients with biliary diseases
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DOI：
10.1016/j.dld.2004.04.006
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发表时间：
2004-09-01
影响因子：
4.5
通讯作者：
Watanabe, T
中科院分区：
文献类型：
--
作者：
Enjoji, M;Yamaguchi, K;Watanabe, T
背景我们已经证明免疫组织化学RCAS 1抗原表达在胆管肿瘤。肝内胆管癌患者血清RCAS 1水平升高的比例也很高。该研究旨在确定与CA 19 - 9相比，RCAS 1的血清水平作为胆道肿瘤的肿瘤标志物是否具有临床意义。对38例胆道癌（胆囊癌、肝内外胆管癌和壶腹癌）患者进行血清RCAS 1和CA 19 -9水平测定。作为对照，还检测了良性胆道疾病患者和健康志愿者的血清样品。我们建立了RCAS 1的阈值为17.5 U/ml，这允许区分恶性和非恶性胆道疾病。与CA 19-9相比，血清RCAS 1对恶性肿瘤的敏感性和特异性更高，并且不受胆汁淤积的影响。RCAS 1水平随病程和临床治疗效果而变化。血清RCAS 1可作为胆管癌的诊断指标，也可作为评价治疗过程中肿瘤进展的指标。我们推测RCAS I是比CA 19 -9更有临床意义的胆道肿瘤血清标志物。(C)2004年意大利胃肠病学编辑由爱思唯尔有限公司出版。保留所有权利。
Background. We have demonstrated inummohistochemically that RCAS1 antigen is expressed in biliary neoplasms. Serum RCAS1 levels are also elevated in a high percentage of patients with intra-hepatic cholangiocarcinoma.Aim. The study was designed to determine whether serum levels of RCAS1 are of clinical significance as a tumour marker for biliary tract tumour, in comparison to CA19-9.Patients and methods. In 38 patients with biliary carcinoma (gallbladder carcinoma, extra-hepatic and intra-hepatic cholangiocarcinoma and ampullary carcinoma), we measured serum RCAS1 and CA19-9 levels. For control, serum samples from patients with benign biliary disease and healthy volunteers were also examined.Results. We established a threshold value for RCAS1 of 17.5 U/ml, which permitted discrimination between malignant and non-malignant biliary diseases. In comparison to CA 19-9, serum RCAS1 was more sensitive and specific for malignancy, and was not influenced by cholestasis. RCAS1 levels varied with respect to the disease course and the effect of clinical treatment.Conclusions. Serum RCAS1 appears to be valuable as a diagnostic index for biliary carcinomas, as well as for evaluating the progression of cancers during therapy. We speculate that RCAS I is a clinically more significant serum marker for biliary neoplasms than CA19-9. (C) 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.