LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN-E CONCENTRATIONS
LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN-E CONCENTRATIONS
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DOI：
10.1126/science.8178175
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发表时间：
1994-05-20
期刊：
影响因子：
56.9
通讯作者：
BEATY, TH
中科院分区：
文献类型：
--
作者：
MARSH, DG;NEELY, JD;BEATY, TH
对来自11个阿米什家庭的170名个体进行的SIB配对分析表明，染色体5q31.1上的五个标记与控制血清总免疫球蛋白E(IgE)浓度的基因连锁。未发现这些标志物与特异性IgE抗体浓度之间的联系。对128对IgE抗体阴性同胞中总IgE的分析证实了与5q31.1连锁的证据，特别是与白细胞介素4基因(IL4)的连锁。分离和最大似然分析的结合为这种联系提供了进一步的证据。这些分析表明，IL4或5q31.1中的邻近基因以非抗原特异性(非同源)的方式调节IgE的产生。
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.