The effects of mild diastolic hypertension on the results of tests of cognitive function in adults 22 to 59 years of age.
The effects of mild diastolic hypertension on the results of tests of cognitive function in adults 22 to 59 years of age.
复制标题
轻度舒张期高血压对 22 至 59 岁成人认知功能测试结果的影响。
DOI：
10.1007/bf02599096
复制
发表时间：
1992
影响因子：
5.7
通讯作者：
Hauck,WW
中科院分区：
文献类型：
--
作者：
Pérez-Stable,EJ;Coates,TJ;Halliday,R;Gardiner,PS;Hauck,WW
目的：为了检验这一假设，轻度舒张期高血压（90至104毫米汞柱）可能会导致无症状损害的认知function.Design：Cross-sectional.Setting：社区参与者招募到一所大学为基础的门诊护理center.Participants：312名男性和女性未经治疗的原发性高血压和47名血压正常的科目，22至59岁的年龄。测量和主要结果：认知功能测试测量的反应时间和准确性，在解释预定的视觉刺激，能力，获取，复制和改变一组任意的刺激-反应协会，记忆和学习的口头信息。选择这些测试是为了检测表现上的细微差异，而不是区分神经正常的人和脑损伤的人。在控制了年龄、性别和受教育程度后，结果显示，血压正常者和高血压者在两项反应时间测量和四项准确性测量方面没有显著差异，这四项测量是在解释预定的视觉刺激、任意刺激-反应关联的测量或七个记忆和学习变量方面。尽管平均值之间差异的置信区间较宽，但不太可能存在临床显著差异。年轻的年龄与更快的反应时间，更少的错误，更好的表现在记忆和学习任务，独立的舒张压byproduct.Conclusions：少数未治疗的轻度高血压对认知功能的影响，在文献中报道可能是由于机会和可疑的临床意义。
Objective:To test the hypothesis that mild diastolic hypertension (90 to 104 mm Hg) may induce asymptomatic impairment of cognitive function.Design:Cross-sectional.Setting:Community participants recruited to a university-based ambulatory care center.Participants:Three hundred twelve men and women with untreated essential hypertension and 47 normotensive subjects, 22 to 59 years of age.Measurements and main results:Cognitive function tests measured reaction time to and accuracy in interpreting predetermined visual stimuli, the ability to acquire, reproduce, and change a set of arbitrary stimulus — response associations, and memory and learning of verbal information. These tests were selected to detect subtle differences in performances as opposed to differentiating neurologically normal persons from brain-damaged persons. After controlling for age, gender, and education, results showed that there was no significant difference between the normotensive and hypertensive subjects in two measures of reaction time to and four measures of accuracy in interpreting predetermined visual stimuli, in the measure of arbitrary stimulus-response associations, or in seven memory and learning variables. Although confidence intervals for the differences between means were wide, clinically significant differences were not likely to be present. Younger age was associated with faster reaction times, fewer errors, and better performance on memory and learning tasks, independent of diastolic blood pressure.Conclusions:The few detectable effects of untreated mild hypertension on cognitive function reported in the literature may be due to chance and are of questionable clinical significance.