REPAIR OF CHEMICAL CARCINOGEN-INDUCED DAMAGE IN DNA OF HUMAN-LYMPHOCYTES AND LYMPHOID-CELL LINES - STUDIES OF THE KINETICS OF REMOVAL OF O-6-METHYLGUANINE AND 3-METHYLADENINE
REPAIR OF CHEMICAL CARCINOGEN-INDUCED DAMAGE IN DNA OF HUMAN-LYMPHOCYTES AND LYMPHOID-CELL LINES - STUDIES OF THE KINETICS OF REMOVAL OF O-6-METHYLGUANINE AND 3-METHYLADENINE
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DOI：
10.1016/0009-2797(86)90053-0
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发表时间：
1986-01-01
影响因子：
5.1
通讯作者：
ROITT, IM
中科院分区：
文献类型：
--
作者：
LAWLEY, PD;HARRIS, G;ROITT, IM
The removal of O6-methylguanine by human lymphoid cells corresponded, with certain assumptions, to a second-order chemical reaction in any given cell. There was a specrum of proficiency in this respect for a considerable number of cells originating from different individuals and it was found that patients with diseases associated with autoimmunity tended to fall into the less proficient groups. E-B virus-induced lymphoid cell lines, derived from proficient, but not relatively deficient, peripheral blood lymphocytes, always (in 9/9 cses) reflected the level of proficiency of the donor lymphocytes with respect to removal of O6-methylguanine. Thus while proficient lymphocytes always produced proficient cell lines, deficient lymphocytes, in 3/8 cases, gave rise to more proficient cell lines. No evidence was found that groups of individuals exist who lack ability to remove 3-methyladenine from DNA, either from their blood lymphocytes or derived lymphoid cell lines.
