Changes in Cognitive Impairment in the Czech Republic
Changes in Cognitive Impairment in the Czech Republic
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DOI：
10.3233/jad-190688
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Cermakova, Pavla
中科院分区：
文献类型：
--
作者：
Seblova, Dominika;Brayne, Carol;Cermakova, Pavla
背景：来自北美和西欧的研究表明，出生队列中认知障碍的趋势稳定或下降。目的：我们旨在研究捷克共和国年龄特异性认知障碍患病率的变化。方法：本研究使用了两个样本，这些样本来自以人口为基础的捷克欧洲健康、老龄化和退休调查。研究比较了第二阶段（2006/2007;n = 1107）和第六阶段（2015;n = 3104）参与者的认知障碍（根据语言流畅性、即时回忆、延迟回忆和时间取向的得分来定义）的年龄特异性患病率。使用逻辑回归来估计波与认知障碍之间的关系，逐步调整社会人口统计学和临床特征。进行了多敏感性分析，重点关注相对认知障碍的替代操作方法、缺失认知数据的影响和生存偏差。结果：最保守的估计表明，认知障碍的年龄特异性患病率下降了五分之一，从2006/2007年的11%下降到2015年的9%。在所有敏感性分析中均观察到下降。这一变化与缺乏运动、高胆固醇管理和教育程度的不同有关。结论：捷克共和国是一个位于中东欧地区的国家，老年人在认知衰老方面取得了积极的进展。更长时间的教育、更好地管理心血管因素和减少缺乏体育活动似乎是至关重要的。
Background: Studies from North America and Western Europe suggest stable or declining trends in impaired cognition across birth cohorts.Objective: We aimed to examine changes in the age-specific prevalence of cognitive impairment in the Czech Republic.Methods: The study used two samples from the population-based Czech Survey on Health, Ageing and Retirement in Europe. Age-specific prevalence of cognitive impairment (defined based on scores in verbal fluency, immediate recall, delayed recall, and temporal orientation) was compared between participants in wave 2 (2006/2007; n = 1,107) and wave 6 (2015; n = 3,104). Logistic regression was used to estimate the association between the wave and cognitive impairment, step-wise adjusting for sociodemographic and clinical characteristics. Multiple sensitivity analyses, focusing on alternative operationalizations of relative cognitive impairment, impact of missing cognitive data, and survival bias, were carried out.Results: The most conservative estimate suggested that the age-specific prevalence of cognitive impairment declined by one fifth, from 11% in 2006/2007 to 9% in 2015. Decline was observed in all sensitivity analyses. The change was associated with differences in physical inactivity, management of high blood cholesterol, and increases in length education.Conclusion: Older adults in the Czech Republic, a country situated in the Central and Eastern European region, have achieved positive developments in cognitive aging. Longer education, better management of cardiovascular factors, and reduced physical inactivity seem to be of key importance.