Human glycemic response and phenolic content of unsweetened cranberry juice
Human glycemic response and phenolic content of unsweetened cranberry juice
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DOI：
10.1089/jmf.2007.531
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Ragsdale, Frances R.
中科院分区：
文献类型：
--
作者：
Wilson, Ted;Singh, Ajay P.;Ragsdale, Frances R.
这项横断面研究确定了酚类成分的非处方蔓越莓汁（CBJ）与高效液相色谱法，并检查了低热量和正常热量的CBJ配方对健康人餐后血糖反应的影响。在这项研究中使用的CBJ含有7个酚酸，3-和5-咖啡酰奎宁酸的主要成分，和15黄酮醇糖苷，与杨梅素-3-半乳糖苷和槲皮素-3-半乳糖苷是最普遍的。CBJ原花青素由三个不同的四聚体和一个七聚体组成，这与基质辅助激光解吸电离飞行时间质谱分析证实。参与者接受以下六种治疗之一：无（无水/饮料）、水（480 mL）、无糖低热量CBJ（38 Cal/480 mL）、正常热量CBJ（280 Cal/480 mL）、等热量正常热量（高果糖玉米糖浆[HFCS]）或等热量低热量饮料。在不接受任何治疗、水或低热量治疗的组中，餐后血糖或胰岛素没有显著差异。相比之下，摄入正常卡路里CBJ和正常卡路里对照饮料导致餐后30分钟血糖浓度显著升高，尽管180分钟后差异不再显著。正常热量CBJ和对照组（HFCS）受试者餐后60分钟血浆胰岛素显著升高，但餐后120分钟无显著差异。摄入CBJ不会影响心率或血压。这项研究表明，消费低热量的CBJ富含以前未表征的三聚体和七聚体原花青素与有利的血糖反应相关，可能对葡萄糖耐量受损的人有益。
This cross-sectional study determined the phenolic composition of an over-the-counter cranberry juice (CBJ) with high-performance liquid chromatography and examined the effects of low- and normal-calorie CBJ formulations on the postprandial glycemic response in healthy humans. The CBJ used in this study contained seven phenolic acids, with 3- and 5-caffeoylquinic acid being the primary components, and 15 flavonol glycosides, with myricetin-3-galactoside and quercetin-3-galactoside being the most prevalent. CBJ proanthocyanidins consisted of three different tetramers and a heptamer, which were confirmed with matrix-assisted laser desorption ionization-time of flight-mass spectrometry analysis. Participants received one of the following six treatments: nothing (no water/beverage), water (480 mL), unsweetened low- calorie CBJ (38 Cal/480 mL), normal-calorie CBJ (280 Cal/480 mL), isocaloric normal calorie (high fructose corn syrup [HFCS]), or isocaloric low- calorie beverages. No significant differences in postprandial blood glucose or insulin were observed in the groups receiving nothing, water, or low- calorie treatments. In contrast, the ingestion of normal-calorie CBJ and normal-calorie control beverage resulted in significantly higher blood glucose concentrations 30 minutes postprandially, although the differences were no longer significant after 180 minutes. Plasma insulin of normal-calorie CBJ and control (HFCS) recipients was significantly higher 60 minutes postprandially, but not significantly different 120 minutes postprandially. CBJ ingestion did not affect heart rate or blood pressure. This study suggests that the consumption of a low-calorie CBJ rich in previously uncharacterized trimer and heptamer proanthocyanidins is associated with a favorable glycemic response and may be beneficial for persons with impaired glucose tolerance.