Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial
Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial
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DOI：
10.1111/j.1600-051x.2010.01632.x
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发表时间：
2011-01-01
影响因子：
6.7
通讯作者：
Tonetti, Maurizio S.
中科院分区：
文献类型：
--
作者：
Griffiths, Gareth S.;Ayob, Rasidah;Tonetti, Maurizio S.
背景以前，我们发现全身应用甲硝唑和阿莫西林能显著改善全身侵袭性牙周炎患者非手术清创的疗效。本研究的目的是观察是否再治疗与抗生素的抗生素将给予安慰剂组的好处相媲美的test group. MethodsThirteen-8的41名受试者，从最初的6个月的试验，完成了第二阶段，再治疗的网站与剩余的口袋>= 5毫米。受试者在第一阶段的安慰剂，接受抗生素的抗生素7天。临床参数收集在2个月后治疗（8个月从基线）。ResultsPatients谁收到抗生素在初始治疗，显示统计学显着改善袋深度减少和改善临床相关阈值以上的网站的百分比，与谁收到抗生素在重新治疗的患者相比。在深囊袋（>= 7 mm）中，平均差异为0.9 mm（p=0.003），在中等囊袋（4-6 mm）中，平均差异为0.4 mm（p=0.036）。对于从>= 5到= 4转换为
P>BackgroundPreviously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non-surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re-treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group.MethodsThirty-eight of 41 subjects, from the initial 6-month trial, completed the second phase, re-treatment of sites with remaining pockets >= 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline).ResultsPatients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re-treatment. In deep pockets (>= 7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4-6 mm) it was 0.4 mm (p=0.036). For pockets converting from >= 5 to = 4 to