METABOLISM OF C-4 AND FACTOR-B IN RHEUMATOID-ARTHRITIS - RELATION TO RHEUMATOID-FACTOR
METABOLISM OF C-4 AND FACTOR-B IN RHEUMATOID-ARTHRITIS - RELATION TO RHEUMATOID-FACTOR
复制标题
DOI：
10.1002/art.1780230806
复制
发表时间：
1980-01-01
影响因子：
--
通讯作者：
VAUGHAN, JH
中科院分区：
文献类型：
--
作者：
KAPLAN, RA;CURD, JG;VAUGHAN, JH
用放射性碘标记的C4 [补体成分4]和因子B测定了18例类风湿关节炎（RA）患者和19例正常对照者的代谢周转率，以估计补体激活经典途径和替代途径中成分消耗的相对比率。通过差异标记的C4和因子B证明了C4的分解代谢率分数（FCR）优于因子B。高钙血症发生在血管外间隙。C4 FCR与溶血试验（rS = 0.72）中测定的类风湿因子（RF）显著相关，测定为IG[免疫球蛋白]G RF（rS = 0.57）和IgM RF（rS = 0.45）。与测量的其他几种抗体无显著相关性。RA是一种全身性的血管外免疫复合物疾病，其中RF免疫复合物主要通过激活补体的经典途径发挥重要的致病作用的假设得到支持。
Metabolic turnover determined by radioiodide labeled C4 [complement component 4] and factor B was studied in 18 patients with rheumatoid arthritis (RA) and 19 normal control subjects as a means of estimating the relative ratio of consumption of components in the classical and alternative pathways of complement activation. Predominance of fractional catabolic rate (FCR) of C4 over factor B was demonstrated with differentially labeled C4 and factor B. The hypercatabolism occurred in the extravascular space. C4 FCR correlated significantly with rheumatoid factor (RF) determined in a hemolytic assay (rS = 0.72), measured as Ig[immunoglobulin]G RF (rS = 0.57), and as IgM RF (rS = 0.45). There were no significant correlations with several other antibodies measured. The hypothesis that RA is a systemic, extravascular immune complex disease, in which RF immune complexes play a significant pathogenetic role principally via activation of the classical pathway of complement is supported.