Alkaloids from the Leaves of Daphniphyllum subverticillatum
Alkaloids from the Leaves of Daphniphyllum subverticillatum
复制标题
来自 Daphniphyllum subverticillatum 叶的生物碱
DOI：
10.1021/np9003799
复制
发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Zhang, Chuan-Rui;Liu, Hong-Bing;Yue, Jian-Min
从轮叶虎皮楠（Daphniphyllum subverticillatum）叶中分得4个新生物碱，即17-羟基虎皮楠碱（17-hydroxydaphnigraciline，1）、次虎皮楠碱A（subdaphnidine A，2）、虎皮楠碱L甲酯（daphnezomine L methyl ester，3）和11-羟基可达虎皮楠碱（11-hydroxycodaphniphylline，4），沿着24个已知类似物。根据光谱方法和化学证据阐明了1-4的结构。Daphnilongeridine（5）对几种肿瘤细胞系显示出细胞毒性，IC 50值在2.4-9.7 μ M范围内，对HMEC人微血管内皮细胞系显示出IC 50为2.7 μ M。
Four new alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC50 values in the range 2.4-9.7 mu M and against the HMEC human microvascular endothelial cell line with an IC50 of 2.7 mu M.