Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with (1)H-MRS and Pittsburgh Compound-B PET.
Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with (1)H-MRS and Pittsburgh Compound-B PET.
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DOI：
10.3174/ajnr.a5143
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Shungu DC
中科院分区：
文献类型：
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作者：
Chiang GC;Mao X;Kang G;Chang E;Pandya S;Vallabhajosula S;Isaacson R;Ravdin LD;Alzheimer's Disease Neuroimaging Initiative;Shungu DC
氧化应激是阿尔茨海默病（Alzheimer's disease，AD）发生发展的重要病理机制。本研究的目的是评估是否谷胱甘肽（GSH）水平，检测非侵入性质子磁共振波谱（1H MRS），与脑淀粉样变性和记忆在一个社区居住队列的正常老年人。本研究前瞻性入组了15例认知正常受试者。所有受试者均接受了GSH的1H MRS、使用淀粉样蛋白示踪剂的正电子发射断层扫描（PET）和使用神经心理状态可重复组合（RBANS）的神经心理测试。谷胱甘肽水平，脑淀粉样变性和记忆之间的关联进行了评估，采用多元回归模型。经载脂蛋白E ε4携带状态校正后，较低的GSH水平与颞区（p=0.03）和顶叶区（p=0.05）较大的脑淀粉样变性相关。GSH和认知得分之间没有显著相关性。本研究发现正常老年人皮质GSH水平与脑淀粉样变性之间存在相关性，表明GSH的1H MRS测量作为早期AD发病机制的非侵入性生物标志物具有潜在作用。
Oxidative stress has been implicated as an important pathological mechanism in the development of Alzheimer’s disease (AD). The purpose of this study was to assess whether glutathione (GSH) levels, detected noninvasively with proton magnetic resonance spectroscopy (1H MRS), are associated with brain amyloidosis and memory in a community-dwelling cohort of normal older adults. Fifteen cognitively normal subjects were prospectively enrolled in this study. All subjects underwent 1H MRS of GSH, a positron emission tomography (PET) scan with an amyloid tracer, and neuropsychological testing using the Repeatable Battery for Neuropsychological Status (RBANS). Associations among GSH levels, brain amyloidosis, and memory were assessed using multivariate regression models. Lower GSH levels were associated with greater brain amyloidosis in the temporal region (p=0.03) and in the parietal (p=0.05) region, adjusted for apolipoprotein E ε4 carrier status. There were no significant associations between GSH and cognitive scores. This study found an association between cortical GSH levels and brain amyloidosis in normal older adults, suggesting a potential role for 1H MRS measures of GSH as a noninvasive biomarker of early AD pathogenesis.