Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves.
Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves.
复制标题
抗体融合可减少小牛实验性小隐孢子虫感染的发生。
DOI：
10.1016/j.vetpar.2012.02.014
复制
发表时间：
2012
影响因子：
2.6
通讯作者：
Riggs,MichaelW
中科院分区：
文献类型：
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作者：
Imboden,Michael;Schaefer,DeborahA;Bremel,RobertD;Homan,EJane;Riggs,MichaelW
微小隐孢子虫是引起新生犊牛腹泻的主要原因之一，给世界范围内的生产者带来了严重的发病率和经济损失。我们先前已经证明了一类新的抗微生物抗体融合物在新生小鼠模型中对C。细小病毒感染在这里，我们将这些产品的有效性测试扩展到小牛（主要目标种属）的实验感染。用C.小卵囊，并用抗体-杀生物剂融合体4 H9-G1-LL 37伴随处理4天。与对照动物相比，这导致疾病严重程度降低。总体临床健康参数显示给药动物显著改善。与对照动物相比，给药组的卵囊脱落减少。控制卵囊脱落是打破奶牛场再感染循环的先决条件。因此，抗体-杀生物剂融合产品具有降低感染对个体动物和畜群的影响的潜力。
Cryptosporidium parvum is one of the main causes of diarrhea in neonatal calves resulting in significant morbidity and economic losses for producers worldwide. We have previously demonstrated efficacy of a new class of antimicrobial antibody fusions in a neonatal mouse model for C. parvum infection. Here, we extend efficacy testing of these products to experimental infection in calves, the principal target species. Neonatal calves were challenged with C. parvum oocysts and concomitantly treated with antibody–biocide fusion 4H9-G1-LL37 over the course of four days. This resulted in reduced severity of the disease when compared to control animals. Overall clinical health parameters showed significant improvement in treated animals. Oocyst shedding was reduced in treated when compared to control animals. Control of oocyst shedding is a prerequisite for breaking the cycle of re-infection on dairy farms. Antibody–biocide fusion products thus have the potential to reduce the impact of the infection in both individual animals and in the herd.