Adaptive immunity in the host-microbiota dialog.
Adaptive immunity in the host-microbiota dialog.
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DOI：
10.1038/mi.2010.60
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发表时间：
2011-01
影响因子：
8
通讯作者：
Elson CO
中科院分区：
文献类型：
--
作者：
Feng T;Elson CO
肠道代表最大的粘膜表面，并且是宿主粘膜免疫系统与肠道微生物群组分之间多方面相互作用的主要部位。宿主对肠道微生物群的免疫反应受到严格控制，同时，微生物群积极塑造肠道对自身的免疫反应。在健康和疾病过程中这些相互作用的欣赏可能会指导治疗方法，以广泛的自身免疫性疾病和炎症性疾病在人类。在这篇综述中，我们将讨论肠道免疫系统，特别是适应性免疫细胞，如何帮助容纳大量的常驻细菌，以及微生物群如何塑造肠道免疫反应以实现互利共生。
The intestinal tract represents the largest mucosal surface and is a major site of multifaceted interactions between the host mucosal immune system and components of the intestinal microbiota. Host immune responses to the commensal microbiota are tightly controlled and meanwhile, the microbiota actively shapes intestinal immune responses to itself. Appreciation of these interactions during health and disease may direct therapeutic approaches to a broad range of autoimmune and inflammatory disorders in humans. In this Review, we will discuss findings on how the intestinal immune system, especially adaptive immune cells, helps accommodate the large number of resident bacteria, and in turn how the microbiota shapes intestinal immune responses to achieve mutualism.