Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country.
Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country.
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在低收入国家进行结核病医学研究的死后研究的可行性和可接受性。
DOI：
10.3389/fimmu.2023.1264351
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发表时间：
2023
影响因子：
7.3
通讯作者：
Cose, Stephen
中科院分区：
文献类型：
--
作者：
Ahimbisibwe, Gift;Nakibuule, Marjorie;Martin Ssejoba, Marvin;Oyamo, David;Mulwana, Rose;Nabulime, Josephine;Babirye, Febronius;Kizito, Musana Abdusalaamu;Lekuya, Herve Monka;Adakun, Akello Suzan;Nalumansi, Daisy;Muryasingura, Stella;Lukande, Robert;Kyazze, Andrew;Baluku, Joseph Baruch;Biraro, Irene Andia;Cose, Stephen
如果我们要在难以治疗或难以接种的疾病（例如艾滋病毒、疟疾或结核病）方面取得新突破，我们必须更好地了解人类感染部位的免疫系统。对于结核病 (TB)，最初的感染部位是肺部，但从结核病患者身上获取肺组织仅限于支气管肺泡灌洗 (BAL) 或痰液取样，或手术切除患病肺组织。我们研究了在乌干达坎帕拉穆拉戈国家转诊医院进行人类结核病尸检研究的可行性。尸检研究使我们有机会比较患病和未患病个体的结核病相关部位和非结核病部位。我们报告说，近亲对同意将其亲属的组织用于医学研究的接受度很高；尸检和组织处理可在死亡后 8 小时内进行；免疫细胞在死亡后 14 小时内仍能保持活力和功能。尸检程序仍然是确定死因和增进我们对传染病的医学和科学认识的宝贵且必不可少的工具。
If we are to break new ground in difficult-to-treat or difficult-to-vaccinate diseases (such as HIV, malaria, or tuberculosis), we must have a better understanding of the immune system at the site of infection in humans. For tuberculosis (TB), the initial site of infection is the lungs, but obtaining lung tissues from subjects suffering from TB has been limited to bronchoalveolar lavage (BAL) or sputum sampling, or surgical resection of diseased lung tissue. We examined the feasibility of undertaking a postmortem study for human tuberculosis research at Mulago National Referral Hospital in Kampala, Uganda. Postmortem studies give us an opportunity to compare TB-involved and -uninvolved sites, for both diseased and non-diseased individuals. We report good acceptability of the next-of-kin to consent for their relative’s tissue to be used for medical research; that postmortem and tissue processing can be undertaken within 8 hours following death; and that immune cells remain viable and functional up to 14 hours after death. Postmortem procedures remain a valuable and essential tool both to establish cause of death, and to advance our medical and scientific understanding of infectious diseases.
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影响因子：
3.7
作者：
Fu X;Yu S;Yang B;Lao S;Li B;Wu C
通讯作者：
Wu C
影响因子：
6.7
作者：
Lin PL;Maiello P;Gideon HP;Coleman MT;Cadena AM;Rodgers MA;Gregg R;O'Malley M;Tomko J;Fillmore D;Frye LJ;Rutledge T;DiFazio RM;Janssen C;Klein E;Andersen PL;Fortune SM;Flynn JL
通讯作者：
Flynn JL
影响因子：
34.3
作者：
Martinez, Leonardo;Cords, Olivia;Liu, Qiao;Acuna-Villaorduna, Carlos;Bonnet, Maryline;Fox, Greg J.;Carvalho, Anna Cristina C.;Chan, Pei-Chun;Croda, Julio;Hill, Philip C.;Lopez-Varela, Elisa;Donkor, Simon;Fielding, Katherine;Graham, Stephen M.;Espinal, Marcos A.;Kampmann, Beate;Reingold, Arthur;Huerga, Helena;Villalba, Julian A.;Grandjean, Louis;Sotgiu, Giovanni;Egere, Uzochukwu;Singh, Sarman;Zhu, Limei;Lienhardt, Christian;Denholm, Justin T.;Seddon, James A.;Whalen, Christopher C.;Garcia-Basteiro, Alberto L.;Triasih, Rina;Chen, Cheng;Singh, Jitendra;Huang, Li-Min;Sharma, Surendra;Hannoun, Djohar;Del Corral, Helena;Mandalakas, Anna M.;Malone, LaShaunda L.;Ling, Du-Lin;Kritski, Afranio;Stein, Catherine M.;Vashishtha, Richa;Boulahbal, Fadila;Fang, Chi-Tai;Boom, W. Henry;Netto, Eduardo Martins;Lemos, Antonio Carlos;Hesseling, Anneke C.;Kay, Alexander;Jones-Lopez, Edward C.;Horsburgh, C. Robert;Lange, Christoph;Andrews, Jason R.
通讯作者：
Andrews, Jason R.
影响因子：
82.9
作者：
Malherbe, Stephanus T.;Shenai, Shubhada;Walzl, Gerhard
通讯作者：
Walzl, Gerhard
影响因子：
15.8
作者：
Maixenchs, Maria;Anselmo, Rui;Munguambe, Khatia
通讯作者：
Munguambe, Khatia