Mimicking Heme Enzymes in the Solid State: Metal-Organic Materials with Selectively Encapsulated Heme
Mimicking Heme Enzymes in the Solid State: Metal-Organic Materials with Selectively Encapsulated Heme
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DOI：
10.1021/ja203068u
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发表时间：
2011-07-13
影响因子：
15
通讯作者：
Vetromile, Carissa M.
中科院分区：
文献类型：
--
作者：
Larsen, Randy W.;Wojtas, Lukasz;Vetromile, Carissa M.
为了进行基本的生命过程，自然界不得不进化出能够合成和操纵复杂分子的血红素酶。这些蛋白质利用嵌入在进化设计的蛋白质口袋中的单个铁卟啉活性位点进行过多的化学反应。我们在此报告的第一类金属有机材料（MOMs），模仿血红素酶的结构和反应性。MOMzyme-1类是基于一个原型的聚合物，HKUST-1，其中催化活性的金属卟啉被选择性地封装在一个“瓶中船”的方式在HKUST-1中存在的三个纳米级笼之一。MOMs提供了无与伦比的永久孔隙率水平，其模块化性质提供了结构和性能的巨大多样性。因此，MOMzyme-1类可以代表血红素仿生催化的新范例，因为它将均相催化剂的活性与单一材料内多相催化系统的稳定性和可回收性相结合。
To carry out essential life processes, nature has had to evolve heme enzymes capable of synthesizing and manipulating complex molecules. These proteins perform a plethora of chemical reactions utilizing a single iron porphyrin active site embedded within an evolutionarily designed protein pocket. We herein report the first class of metal-organic materials (MOMs) that mimic heme enzymes in terms of both structure and reactivity. The MOMzyme-1 class is based upon a prototypal MOM, HKUST-1, into which catalytically active metalloporphyrins are selectively encapsulated in a "ship-in-a-bottle" fashion within one of the three nanoscale cages that exist in HKUST-1. MOMs offer unparalleled levels of permanent porosity and their modular nature affords enormous diversity of structures and properties. The MOMzyme-1 class could therefore represent a new paradigm for heme biomimetic catalysis since it combines the activity of a homogeneous catalyst with the stability and recyclability of heterogeneous catalytic systems within a single material.