Effect of age-stiffening tissues and intraocular pressure on optic nerve damages.
Effect of age-stiffening tissues and intraocular pressure on optic nerve damages.
复制标题
年龄硬化组织和眼压对视神经损伤的影响。
DOI：
10.3970/mcb.2012.009.157
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
D. C. Lam
中科院分区：
文献类型：
--
作者：
L. K. Leung;M. Ko;D. C. Lam
在老年人中，眼组织的硬化与青光眼有统计学联系。在这项研究中，年龄硬化的影响筛板，原发性青光眼神经损伤的网站，使用计算有限元分析建模。我们发现，昏迷性神经损伤和周边视力丧失的行为可以现象学建模的剪切损伤标准。使用该损害标准，估计30岁轻度高血压25 mmHg眼内压（IOP）的潜在视力丧失为4%。当IOP升高至35 mmHg时，潜在视力丧失上升至45%; 35至60岁的年龄硬化使潜在视力丧失增加至52%。这些结果表明，虽然IOP在青光眼损害中起着核心作用，但年龄硬化促进了青光眼损害，可能是导致老年人青光眼发病率高于普通人群的主要因素。
Age-stiffening of ocular tissues is statistically linked to glaucoma in the elderly. In this study, the effects of age-stiffening on the lamina cribrosa, the primary site of glaucomatous nerve damages, were modeled using computational finite element analysis. We showed that glaucomatous nerve damages and peripheral vision loss behavior can be phenomenologically modeled by shear-based damage criterion. Using this damage criterion, the potential vision loss for 30 years old with mild hypertension of 25 mmHg intraocular pressure (IOP) was estimated to be 4%. When the IOP was elevated to 35 mmHg, the potential vision loss rose to 45%; and age-stiffening from 35 to 60 years old increased the potential vision loss to 52%. These results showed that while IOP plays a central role in glaucomatous damages, age-stiffening facilitates glaucomatous damages and may be the principal factor that resulted in a higher rate of glaucoma in the elderly than the general population.
影响因子：
13.7
作者：
Katz, J;Gilbert, D;Sommer, A
通讯作者：
Sommer, A
影响因子：
4.1
作者：
Quigley, HA
通讯作者：
Quigley, HA
影响因子：
4.4
作者：
Girard MJ;Suh JK;Bottlang M;Burgoyne CF;Downs JC
通讯作者：
Downs JC