Pearls and pitfalls of food challenges in infants
Pearls and pitfalls of food challenges in infants
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DOI：
10.2500/aap.2019.40.4187
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发表时间：
2019-01-01
影响因子：
2.8
通讯作者：
Greenhawt, Matthew
中科院分区：
文献类型：
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作者：
Greenhawt, Matthew
口服食物挑战（OFC）被认为是评估任何年龄患者疑似食物过敏的诊断标准标准程序。这可以通过公开或盲目的挑战来完成。近年来，开放式OFC已成为一种可接受且实用的办公实践。随着新的早期花生引入指南的出现，迫切需要对 4 至 12 个月大的婴儿进行 OFC。最近多项随机对照临床试验的经验表明，此类 OFC 既安全又可行，尽管临床环境中的提供者对该人群使用 OFC 的舒适度和经验程度尚不清楚。这篇综述详细介绍了对婴儿进行 OFC 的基本特征，以帮助指导执业过敏症专科医生如何建立他或她的办公室并最好地完成这一非常重要的程序。
An oral food challenge (OFC) is considered the diagnostic criterion standard procedure for evaluation of a suspected food allergy in patients of any age. This can be accomplished as either an open or a blinded challenge. In recent years, the open OFC has become an acceptable and practical office-based practice. With the advent of new early peanut introduction guidelines, there is a critical need to potentially perform OFC in very young infants between the ages of 4 and 12 months of life. Experience from multiple recent randomized controlled clinical trials indicates that such OFCs are both safe and feasible, although the extent to which providers in the clinical setting are comfortable and experienced with OFCs in this population is unclear. This review detailed the essential features of performing an OFC in an infant to help guide the practicing allergist in how to set up his or her office and best accomplish this very important procedure.