Multiple brain tumors of diffuse large B cell lymphoma in a patient with lymphoplasmacytic lymphoma: PCR and DNA sequence analysis show evidence show evidence of differences in clonality of two B cell malignancies
Multiple brain tumors of diffuse large B cell lymphoma in a patient with lymphoplasmacytic lymphoma: PCR and DNA sequence analysis show evidence show evidence of differences in clonality of two B cell malignancies
复制标题
DOI：
10.2169/internalmedicine.43.990
复制
发表时间：
2004-10-01
影响因子：
1.2
通讯作者：
Maruyama, K
中科院分区：
文献类型：
--
作者：
Tojo, K;Hattori, T;Maruyama, K
我们在一位75岁患有巨球蛋白血症（WM）的男性病人身上发现多发性弥漫性大B细胞淋巴瘤（DLBL）。连续出现椎旁和皮下多发结节，发病后4个月死亡。我们通过聚合酶链反应（PCR）分析和石蜡包埋切片免疫球蛋白重链测序研究了B细胞单克隆性。脑肿瘤的PCR产物显示出与其他切片不同的重排模式。DLBL与WM的共同发生是罕见的，一些研究人员已经研究了这两种恶性肿瘤的克隆性。这个病例很重要，因为DLBL脑肿瘤与WM同时发生，使我们能够证明DLBL和WM具有不同的克隆性。
Multiple brain tumors of diffuse large B cell lymphoma (DLBL) were observed in a 75-year-old man with Waldenstrom's macroglobulinemia (WM). Paravertebral and multiple subcutaneous nodules occurred in succession and he died 4 months after onset. We investigated B cell monoclonality by means of polymerase chain reaction (PCR) analysis and sequencing of the immunoglobulin heavy chain of paraffin-embedded sections. The PCR product of the brain tumors showed a different rearrangement pattern from those of the other sections. The co-occurrence of DLBL with WM is rare, and some investigators have examined the clonality of the two malignancies. This case is important because DLBL brain tumors co-occurred with WM, enabling us to prove that DLBL and WM have different clonality.