Interaction of COMT val158met and externalizing behavior: relation to prefrontal brain activity and behavioral performance.
Interaction of COMT val158met and externalizing behavior: relation to prefrontal brain activity and behavioral performance.
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COMT val158met 与外化行为的相互作用：与前额叶大脑活动和行为表现的关系。
DOI：
10.1016/j.neuroimage.2012.01.097
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发表时间：
2012
期刊：
影响因子：
5.7
通讯作者：
Gray,JeremyR
中科院分区：
文献类型：
--
作者：
Shehzad,Zarrar;DeYoung,ColinG;Kang,Yoona;Grigorenko,ElenaL;Gray,JeremyR
A promising approach in neuroimaging studies aimed at understanding effects of single genetic variants on behavior is the study of gene–trait interactions. Variation in the catechol-O-methyl-transferase gene (COMT) is associated with the regulation of dopamine levels in the prefrontal cortex and with cognitive functioning. Given the involvement of dopaminergic neurotransmission in externalizing behavior, a trait characterized by impulsivity and aggression, especially in men, externalizing (as a trait) may index a set of genetic, environmental, and neural characteristics pertinent to understanding phenotypic effects of genetic variation in the COMT gene. In the current study, we used a gene–trait approach to investigate effects of the COMT val158met polymorphism and externalizing on brain activity during moments involving low or high demands on cognitive control. In 104 male participants, interference-related activation depended conjointly on externalizing and val158met: stronger activation in the dorsal anterior cingulate and lateral prefrontal cortex was found for val/val individuals with high trait externalizing while stronger activation in cingulate motor areas and sensorimotor precuneus was found for met/met individuals with low externalizing. Our results suggest that the val/val genotype, coupled with high levels of trait externalizing, lowers the efficiency of stimulus conflict resolution, whereas the met/met genotype, coupled with low levels of externalizing, lowers the efficiency of response selection.
