B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment.
B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment.
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DOI：
10.1080/2162402x.2017.1294296
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发表时间：
2017
期刊：
影响因子：
7.2
通讯作者：
Karagiannis SN
中科院分区：
文献类型：
--
作者：
Chiaruttini G;Mele S;Opzoomer J;Crescioli S;Ilieva KM;Lacy KE;Karagiannis SN
肿瘤内成熟B细胞和抗体组分的证据以及恶性黑色素瘤中与良好预后相关的报道表明，体液免疫可能参与抗肿瘤防御。B细胞可能在努力提供免疫保护的同时受到促肿瘤免疫耐受的影响，可能产生多种功能，包括抗原加工和呈递、细胞因子介导的信号传导、抗体类别转换、表达和分泌。我们回顾了支持B细胞可能对抗或促进恶性黑色素瘤的多方面免疫机制的关键证据，并讨论了它们潜在的转化意义。剖析肿瘤相关体液反应的作用可以为未来的治疗途径提供信息。
Evidence of tumor-resident mature B cell and antibody compartments and reports of associations with favorable prognosis in malignant melanoma suggest that humoral immunity could participate in antitumor defense. Likely striving to confer immunological protection while being subjected to tumor-promoting immune tolerance, B cells may engender multiple functions, including antigen processing and presentation, cytokine-mediated signaling, antibody class switching, expression and secretion. We review key evidence in support of multifaceted immunological mechanisms by which B cells may counter or contribute to malignant melanoma, and we discuss their potential translational implications. Dissecting the contributions of tumor-associated humoral responses can inform future treatment avenues.