Fond Memories of Professor Sen-itiroh Hakomori
Fond Memories of Professor Sen-itiroh Hakomori
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箱森先生的美好回忆
DOI：
10.1093/jb/mvac039
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Hosono Masahiro
中科院分区：
文献类型：
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作者：
Inokuchi Jin-ichi;Hosono Masahiro
《生物化学杂志》（JB）今年庆祝了100周年，我们的导师，已故的Sen-itiroh Hakomori博士，分享了一种深厚而持久的关系。1959年，箱森博士与他的导师Hajime Masamune博士一起搬到了东北药科大学的癌症研究所（CRI）。遗憾的是，Masamune教授突然去世，Hakomori博士在30岁时成为实验室的教授。JB是第一个发表文章的英文生物化学杂志，其中Hakomori博士被列为通讯作者（1）。在他在该实验室的4年里，他的工作逐渐从粘蛋白的癌变转移到糖脂的癌变，跟随Masamune博士实验室的趋势。他在离开仙台之前在JB发表了七篇论文。第七篇论文描述了糖的完全甲基化，这种技术后来被广泛称为“Hakomori方法”（2）。该方法基于二甲亚砜和氢化钠与糖产生的甲基亚磺酰基碳负离子的反应。这是一种高度创新的方法，可以通过碘甲烷以高产率在不需要专门设备的单一反应中完全甲基化醇钠中间体，包括难以反应的酸性糖，并已广泛应用于聚糖结构分析。这篇论文在Web of Science上的被引次数为5273次。
The Journal of Biochemistry (JB), which celebrated its 100th anniversary this year, and our mentor, the late Dr Sen-itiroh Hakomori, shared a deep and long-lasting relationship. In 1959, Dr Hakomori moved to the Cancer Research Institute (CRI) of Tohoku Pharmaceutical University, together with his mentor, Dr Hajime Masamune. Regrettably, Prof. Masamune passed away suddenly and Dr Hakomori consequently became the head of the laboratory as a Professor at the age of 30 years. JB was the first English-language biochemistry journal to publish an article in which Dr Hakomori was listed as a corresponding author (1).During his 4 years in this laboratory, his work shifted gradually from cancerous changes in mucoproteins to those in glycolipids, following the trend of Dr Masamune’s laboratory. He published seven papers in JB before leaving Sendai. The seventh paper described complete methylation of sugars, a technique that subsequently became widely known as the ‘Hakomori method’(2). The method is based on a reaction of methylsulfinyl carbanions produced by dimethylsulfoxide and sodium hydride with sugars. It is a highly innovative method that makes possible complete methylation of sodium alkoxide intermediates, including difficult-to-react acidic sugars, by methyl iodide, in high yield, in a single reaction that does not require specialized equipment, and has been widely applied in glycan structural analysis. The number of citations of this paper on Web of Science to date is 5273.