BRAIN-DERIVED NEUROTROPHIC FACTOR PREVENTS NEURONAL DEATH INVIVO
BRAIN-DERIVED NEUROTROPHIC FACTOR PREVENTS NEURONAL DEATH INVIVO
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DOI：
10.1038/331261a0
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发表时间：
1988-01-21
期刊：
影响因子：
64.8
通讯作者：
BARDE, YA
中科院分区：
文献类型：
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作者：
HOFER, MM;BARDE, YA
发育中的脊椎动物神经元被认为依赖于它们的目标领域中存在的特定神经营养蛋白的生存。这些蛋白质的有限可用性不允许最初支配靶点的所有神经元存活，导致广泛观察到的自然发生的神经元死亡现象1。尽管已经报道了多种蛋白质促进组织培养中神经元的存活2 -4，但是这些蛋白质在体内增加神经元数量和/或减少神经元死亡的证明仅可能使用神经生长因子（NGF）5-7。神经营养蛋白在正常发育过程中调节神经元存活的概念的推广关键取决于神经元在体内的存活可以通过施用不同于NGF的神经营养蛋白而增加的证明。我们在这里报告，这是脑源性神经营养因子的情况下，从中枢神经系统纯化的蛋白质的丰度极低。
Developing vertebrate neurons are thought to depend for their survival on specific neurotrophic proteins present in their target fields1. The limited availability of these proteins does not allow the survival of all neurons initially innervating a target, resulting in the widely observed phenomenon of naturally occurring neuronal death1. Although a variety of proteins have been reported to promote the survival of neurons in tissue culture2–4, the demonstration that these proteins increase neuronal numbers and/or decrease neuronal deathin vivohas only been possible with nerve growth factor (NGF)5–7. The generalization of the concept that neurotrophic proteins regulate neuronal survival during normal development critically depends on the demonstration that the survival of neuronsin vivocan be increased by the administration of a neurotrophic protein different from NGF. We report here that this is the case with brain-derived neurotrophic factor, a protein of extremely low abundance purified from the central nervous system.