Structural basis of cell apoptosis and necrosis in TNFR signaling
Structural basis of cell apoptosis and necrosis in TNFR signaling
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TNFR 信号传导中细胞凋亡和坏死的结构基础。
DOI：
10.1007/s10495-014-1061-5
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发表时间：
2015-02-01
期刊：
影响因子：
7.2
通讯作者：
Li, Jixi
中科院分区：
文献类型：
--
作者：
Huang, Jing;Yu, Shaoning;Li, Jixi
肿瘤坏死因子受体（TNFRs）在先天性免疫和适应性免疫中起重要作用。根据条件，TNFR诱导多种细胞命运，包括细胞存活、细胞凋亡和细胞程序性坏死。本文就TNFR信号通路的结构研究进展作一综述。高阶信号复合物的结构基础，包括DISC，ripoptosome，necrosome，和RIP 3/MLKL复合物，可以为理解细胞信号级联的生物物理学原理提供新的见解。
The tumor necrosis factor receptors (TNFRs) play essential roles in innate and adaptive immunity. Depending on conditions, TNFR induces multiple cell fates including cell survival, cell apoptosis, and cell programmed necrosis. Here, we review recent progress in structural studies of the TNFR signaling pathway. The structural basis for the high order signal complexes, including the DISC, ripoptosome, necrosome, and RIP3/MLKL complex, may provide novel insights for understanding the biophysical principles of cell signaling cascades.