Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
复制标题
二氢叶酸还原酶脂溶性抑制剂对培养物和大鼠感染模型中卡氏肺孢子虫的活性。
DOI：
10.1128/aac.31.9.1323
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发表时间：
1987
影响因子：
4.9
通讯作者：
Smith,JW
中科院分区：
文献类型：
--
作者：
Queener,SF;Bartlett,MS;Jay,MA;Durkin,MM;Smith,JW
Trimetrexate and BW301U (piritrexim isethionate), lipid-soluble inhibitors of dihydrofolate reductase, are potent inhibitors of the growth of Pneumocystis carinii in culture with WI-38 cells. Inhibition was observed with 0.1 microgram of trimetrexate or BW301U per ml. Trimethoprim is ineffective at 100 micrograms/ml in this culture system. Both trimetrexate and BW301U were effective as prophylactic agents against P. carinii pneumonia in rats; trimetrexate at 7.5 mg/kg protected 9 of 10 rats, and BW301U at 5 mg/kg protected 4 of 10.
