Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study
Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study
复制标题
DOI：
10.1183/09031936.05.00020804
复制
发表时间：
2005-03-01
影响因子：
24.3
通讯作者：
Sahovic, E
中科院分区：
文献类型：
--
作者：
Khalid, M;Al Saghir, A;Sahovic, E
闭塞性细支气管炎（BO）是异基因骨髓移植（BMT）后严重的非感染性肺部并发症。阿奇霉素，一种大环内酯类抗生素，可能通过其抗炎作用对BO产生有益作用。本研究的目的是探讨阿奇霉素对BO合并BMT患者肺功能试验（PFT）的潜在影响。对153例BMT后患者的PFT进行了随访; 153例患者中有8例（12%）在PFT中出现阻塞性气道疾病，沿着高分辨率胸部计算机断层扫描的BO特征性结果。阿奇霉素500 mg q.d.每周3次，每次250毫克，持续12周。用力肺活量均获得临床显著改善，其中平均报告的（95%置信区间）增加为410 mL（0.16-0.65），平均改善21.57%，在1秒用力呼气量方面，阿奇霉素治疗闭塞性细支气管炎的疗效值得进一步研究。
Bronchiolitis obliterans (BO) is a serious noninfectious pulmonary complication following allogeneic bone marrow transplantation (BMT). Azithromycin, a macrolide antibiotic, may have a beneficial effect in BO through its anti-inflammatory effect. The aim of the current study was to investigate the potential effect of azithromycin on pulmonary function tests (PFTs) in BO complicating BMT.PFTs of 153 post-BMT patients were followed; eight patients out of 153 (12%) developed obstructive airway disease on their PFTs, along with characteristic findings of BO on high-resolution computed tomography of the chest. These patients were given azithromycin 500 mg q.d. for 3 days, followed by 250 mg three times a week for 12 weeks.Clinically significant improvements were achieved both in forced vital capacity, where the mean (95% confidence interval) increase reported was 410 mL (0.16-0.65), which was an average improvement of 21.57%, and in the forced expiratory volume in one second, where the mean increase noticed was 280 mL (0.10-0.44), which was an average improvement of 20.58%.In conclusion, the potential role of azithromycin in the treatment of bronchiolitis obliterans is intriguing and it warrants further testing.