A photochemical route for efficient cyclopeptide formation with a minimum of protection and activation chemistry
A photochemical route for efficient cyclopeptide formation with a minimum of protection and activation chemistry
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DOI：
10.1021/ja025804o
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发表时间：
2002-09-18
影响因子：
15
通讯作者：
Molis, A
中科院分区：
文献类型：
--
作者：
Griesbeck, AG;Heinrich, T;Molis, A
一个精心设计的协议，它允许有效的转化二，三，和四肽成环肽与最低限度的保护和活化化学使用光诱导的电子转移引发的脱羧N-邻苯二甲酰肽导致在最初形成的碳自由基之间的C-C耦合。
An elaborated protocol is described which allows the efficient transformation of di-, tri-, and tetrapeptides into cyclopeptides with a minimum of protection and activation chemistry using the photoinduced electron transfer initiated decarboxylation ofN-phthaloyl peptides resulting in C−C coupling between the initially formed carbon radicals.