C3 glomerulopathy in a patient with a history of post-infectious glomerulonephritis.
C3 glomerulopathy in a patient with a history of post-infectious glomerulonephritis.
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有感染后肾小球肾炎病史的患者发生 C3 肾小球病。
DOI：
10.1007/s00467-023-06177-5
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Gattineni,Jyothsna
中科院分区：
文献类型：
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作者：
Nnadi,Nicole;Hendricks,AllenR;Torrealba,Jose;Drake,KeriA;Gattineni,Jyothsna
感染后肾小球肾炎（PIGN）是一种免疫复合物介导的肾小球损伤，由于感染而发生，最常见于儿童A组β溶血性链球菌。C3肾小球病（C3G）是一种独特的临床病理实体，继发于补体替代途径失调，包括C3肾小球肾炎（C3GN）和致密沉积病（DDD）。虽然大多数PIGN患者在发病后6-8周补体水平达到正常的完全缓解，但C3G患者继续存在补体不足，进行性肾脏疾病的发生率很高。在这里，我们报告一名患者在三年前首次出现PIGN后被诊断为致密沉积病。虽然目前的文献仍在继续探索PIGN和C3G的重叠和区别特征，包括补体替代途径的潜在缺陷如何共同导致这两种疾病，但本病例进一步说明了认识肾小球肾炎患儿PIGN和C3G的临床致病特征的重要性。
Post-infectious glomerulonephritis (PIGN) is an immune complex mediated glomerular injury occurring because of an infection, most commonly with group A beta-hemolytic streptococcus in children. C3 glomerulopathy (C3G) is a distinct clinicopathological entity occurring secondary to dysregulation of alternate complement pathway encompassing both C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). While most patients with PIGN attain complete remission with normalized complement levels by 6–8 weeks after presentation, patients with C3G continue to have hypocomplementemia with high rates of progressive kidney disease. Here, we report a patient diagnosed with dense deposit disease after his initial presentation with PIGN three years prior. While current literature continues to explore the overlapping and distinguishing features of PIGN and C3G, including how underlying defects in the alternate complement pathway may commonly contribute to both diseases, this case further exemplifies the importance of recognizing the clinico-pathogenic features of PIGN and C3G in pediatric patients with glomerulonephritis.
影响因子：
4.6
作者：
Khalighi MA;Wang S;Henriksen KJ;Bock M;Keswani M;Meehan SM;Chang A
通讯作者：
Chang A
补体抑制剂治疗肾脏疾病。
DOI：
10.1093/ndt/gfad079
发表时间：
2023
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
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作者：
Benjamin Wooden;Blanca Tarragon Estebanez;M. Navarro;A. Bomback
通讯作者：
A. Bomback