THE RELATIONSHIP BETWEEN LOW KM ALDEHYDE DEHYDROGENASE PHENOTYPE AND DRINKING BEHAVIOR IN JAPANESE
THE RELATIONSHIP BETWEEN LOW KM ALDEHYDE DEHYDROGENASE PHENOTYPE AND DRINKING BEHAVIOR IN JAPANESE
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DOI：
10.15288/jsa.1992.53.170
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
HARFORD, TC
中科院分区：
文献类型：
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作者：
HIGUCHI, S;MURAMATSU, T;HARFORD, TC
通过对日本人（N = 282）的发根裂解物等电聚焦、面部潮红和饮酒模式测定低Km醛脱氢酶（ALDH 2）表型之间的关系。不活跃ALDH2的男性饮酒量明显少于活跃ALDH2的男性。尽管这种影响不太明显，但在女性中也发现了类似的关系。确定了两种类型的潮红反应：一种是由于无活性的ALDH 2，另一种与这种同工酶的变体形式无关。这些冲洗类型之间的显着差异，在抑制影响饮酒模式，被注意到。近86%的报告总是面部潮红的受试者被证明具有非活性ALDH 2，而不频繁潮红和没有潮红与活性ALDH 2相关。因此，面部潮红可用作ALDH2表型的指标。
The relationship between the low Km aldehyde dehydrogenase (ALDH2) phenotype determined by the isoelectric focusing of hair root lysates, facial flushing and alcohol drinking patterns in Japanese (N = 282) was examined. Men who had inactive ALDH2 drank significantly less alcohol than those with active ALDH2. Although the effect was less noticeable, a similar relationship was detected in women. Two types of flushing responses were determined: one due to the inactive ALDH2, the other unrelated to this variant form of the isozyme. A striking difference between these flushing types, in terms of the inhibitory influence over drinking patterns, was noted. Nearly 86% of the subjects who reported always flushing in the face were shown to have inactive ALDH2, whereas, infrequent flushing and absence of flushing were associated with active ALDH2. Thus, facial flushing may be used as an indicator of ALDH2 phenotype.