Immunohistochemical localization of cocaine- and amphetamine-regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)
Immunohistochemical localization of cocaine- and amphetamine-regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)
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DOI：
10.1002/cne.24028
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发表时间：
2016-12-15
影响因子：
2.5
通讯作者：
Wylie, Douglas R.
中科院分区：
文献类型：
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作者：
Gutierrez-Ibanez, Cristian;Iwaniuk, Andrew N.;Wylie, Douglas R.
可卡因和安非他明调节的转录肽 (CARTp) 是在脊椎动物大脑中充当神经递质的神经肽。 CARTp 的表达已在硬骨鱼、两栖动物和几种哺乳动物物种中得到表征，但在爬行动物和鸟类中不存在比较数据。在这项研究中，我们展示了两种鸟类大脑中针对 CART 肽 (CARTp-ir) 的免疫反应性分布：鸽子 (Columba livia) 和斑胸草雀 (Taeniopygia guttata)。我们在两者的大脑中都发现了 CARTp-ir 细胞和终端，但这两个物种之间没有重大差异。与哺乳动物、硬骨鱼和两栖动物一样，CARTp-ir 末端和细胞在大脑皮层下区域丰富，特别是纹状体和伏隔核。我们还在下丘脑中发现了CARTp-ir细胞和终末，在黑质、腹侧被盖区、导水管周围灰质、臂旁核和背侧迷走神经复合体中发现了大量CARTp-ir终末。然而，与其他脊椎动物不同的是，CARTp-ir 并未在嗅球中发现。此外，大脑皮层或海马结构中几乎没有CARTp-ir，小脑中也几乎没有CARTp-ir。 CARTp 在鸟类的大脑皮层下、下丘脑和背侧迷走神经复合体中的保守表达表明，CARTp 的一些功能，例如食物摄入的调节以及与社会控制网络和中脑边缘奖励系统的相互作用，在脊椎动物中是保守的。 J.Comp。内罗尔。 524:3747-3773，2016 年。(c) 2016 年 Wiley 期刊公司。
Cocaine- and amphetamine-regulated transcript peptides (CARTp) are neuropeptides that act as neurotransmitters in the brain of vertebrates. The expression of CARTp has been characterized in teleosts, amphibians, and several mammalian species, but comparative data in reptiles and birds are nonexistent. In this study, we show the distribution of immunoreactivity against CART peptides (CARTp-ir) in the brains of two bird species: the pigeon (Columba livia) and zebra finch (Taeniopygia guttata). We found CARTp-ir cells and terminals in the brains of both, but no major differences between the two species. As in mammals, teleost fish, and amphibians, CARTp-ir terminals and cells were abundant in subpallial regions, particularly the striatum and nucleus accumbens. We also found CARTp-ir cells and terminals in the hypothalamus, and a large number of CARTp-ir terminals in the substantia nigra, ventral tegmental area, periaqueductal gray, parabrachial nucleus, and dorsal vagal complex. However, in contrast to other vertebrates, CARTp-ir was not found in the olfactory bulb. In addition there was almost no CARTp-ir in the pallium or the hippocampal formation, and little CARTp-ir in the cerebellum. The conserved expression of CARTp in the subpallium, hypothalamus, and dorsal vagal complex of birds suggests that some of the functions of CARTp, such as regulation of food intake and interactions with the social control network and mesolimbic reward system, are conserved among vertebrates. J. Comp. Neurol. 524:3747-3773, 2016. (c) 2016 Wiley Periodicals, Inc.