HEART-RATE AND CARDIOVASCULAR MORTALITY - THE FRAMINGHAM-STUDY
HEART-RATE AND CARDIOVASCULAR MORTALITY - THE FRAMINGHAM-STUDY
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DOI：
10.1016/0002-8703(87)90666-1
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发表时间：
1987-06-01
影响因子：
4.8
通讯作者：
CUPPLES, LA
中科院分区：
文献类型：
--
作者：
KANNEL, WB;KANNEL, C;CUPPLES, LA
基于1876例总死亡和894例心血管死亡（从5070例入组研究时无心血管疾病的受试者中演变而来），检查了Frachial队列30年随访期间两年一次ECG检查的静息心率与死亡率的关系。在所有年龄段的男性和女性中，全因、心血管和冠状动脉死亡率与每两年测定一次的先前心率相关，呈递增趋势。在男性中观察到的与心血管疾病的联系比女性中更令人印象深刻，这与相关的心血管危险因素无关，冠心病事件后的病死率也随着先前心率的增加而增加，并且在35至64岁的男性中，由于猝死而导致的冠心病死亡比例随着心率的增加而显著增加。在高心率下，非心血管疾病死亡人数也大幅增加，心血管疾病导致的所有死亡比例并不随心率增加而增加。还注意到心率更快的心血管死亡人数增加，不包括中期明显心血管疾病的死亡人数，这表明其影响与既存心脏损伤无关。
The relation of resting heart rate on biennial ECG examinations to mortality rates over 30 years of follow-up of the Framingham cohort was examined based on 1876 total deaths and 894 cardiovascular deaths, evolving out of 5070 subjects free of cardiovascular disease at entry into the study. In both sexes, at all ages, all-cause, cardiovascular, and coronary mortality rates increased progressively in relation to antecedent heart rates determined biennially. A more impressive association to cardiovascular disease was observed in men than in women, which was independent of associated cardiovascular risk factors.Case fatality rates following coronary events also increased with antecedent heart rate and the fraction of coronary deaths as sudden death increased strikingly with heart rate in men 35 to 64 years of age. There was also a substantial excess of noncardiovascular deaths at high heart rates, and the proportion of all deaths resulting from cardiovascular disease did not increase with heart rate. The excess cardiovascular deaths with more rapid heart rates were also noted, excluding those with interim overt cardiovascular disease, suggesting an effect independent of preexisting cardiac damage.