Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor
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DOI：
10.3892/or_00000666
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发表时间：
2010-02-01
期刊：
影响因子：
4.2
通讯作者：
Petros, John A.
中科院分区：
文献类型：
--
作者：
Czarnecka, Anna M.;Klemba, Aleksandra;Petros, John A.
乳腺癌是全世界最常诊断出的女性癌症。尽管20多年来，这种疾病的分子遗传学一直是许多项目的焦点，但临床上使用的预后市场数量仍然不能令人满意。许多乳腺癌研究都报道了线粒体 DNA 突变。为了研究线粒体遗传多态性在乳腺癌发展中的可能作用，我们分析了癌症样本及其相应正常组织中的 NADH 脱氢酶基因序列。我们检测到线粒体DNA多态性的发生率增加，特别是非常罕见的多态性，例如A4727G、G9947A、A10044G、A10283G、T11233C和C11503T。我们的报告支持这样的观点，即线粒体DNA多态性为乳腺癌的发展建立了特定的遗传背景，并且线粒体DNA分析可能有助于选择应接受强化筛查和早期检测计划的人群。
Breast cancer is the most frequently diagnosed female cancer all over the world. Although the molecular genetics of this disease has been the focus of many projects for over 20 years, the number of prognostic markets used in clinics is still unsatisfactory. Mitochondrial DNA mutations have been reported in many breast cancer studies. To investigate the possible role of mitochondrial inherited polymorphisms in breast cancer development we analyzed the sequence of NADH-dehydrogenase genes in cancer samples and their corresponding normal tissues. We detected increased incidence of mtDNA polymorphisms, in particular very rare polymorphisms such as A4727G, G9947A, A10044G, A10283G, T11233C, and C11503T. Our report supports the notion that mtDNA polymorphisms establish a specific genetic background for breast cancer development and that mtDNA analysis may help in selection of cohorts that should undergo intensive screening and early detection programs.