Additive Prognostic Value of Coronary Flow Reserve in Patients With Chest Pain Syndrome and Normal or Near-Normal Coronary Arteries
Additive Prognostic Value of Coronary Flow Reserve in Patients With Chest Pain Syndrome and Normal or Near-Normal Coronary Arteries
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DOI：
10.1016/j.amjcard.2008.10.033
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发表时间：
2009-03-01
影响因子：
2.8
通讯作者：
Picano, Eugenio
中科院分区：
文献类型：
--
作者：
Sicari, Rosa;Rigo, Fausto;Picano, Eugenio
在冠状动脉造影正常和胸痛的患者中，药物负荷超声心动图可以确定预后较差的一组患者。目前，在血管扩张剂负荷超声心动图中，左前降支(LAD)的冠脉血流储备(CFR)可以与室壁运动分析相结合。本研究的目的是评估在应激状态下冠状动脉和室壁运动正常的患者的CFR反应的预后价值。我们选择了394例患者(男性171例，年龄61+/-11岁)，接受了潘生丁负荷超声心动图(0.84 mg/kg，6分钟)，并用二维超声心动图和多普勒超声评价左前降支的CFR。所有患者的血管造影结果均无显著差异(
In patients with angiographically normal coronary arteries and chest pain, pharmacologic stress echocardiography can identify a subgroup of patients with a less benign prognosis. Coronary flow reserve (CFR) in the left anterior descending artery (LAD) can currently be combined with wall motion analysis during vasodilator stress echocardiography. The aim of this study was to assess the prognostic value of CFR response in patients with normal coronary arteries and normal wall motion during stress. We selected 394 patients (171 men, 61 +/- 11 years of age) who underwent dipyridamole stress echocardiography (0.84 mg/kg over 6 minutes) with 2-dimensional echocardiography and CFR evaluation of the LAD by Doppler. All had angiographically nonsignificant (