Serum levels of five tumor markers for lung cancer in patients with chronic renal failure.
Serum levels of five tumor markers for lung cancer in patients with chronic renal failure.
复制标题
慢性肾功能衰竭患者肺癌五种肿瘤标志物的血清水平。
DOI：
10.3892/or.5.2.389
复制
发表时间：
1998
期刊：
影响因子：
4.2
通讯作者：
T. Nakai
中科院分区：
文献类型：
--
作者：
F. Nomura;A. Koyama;M. Ishijima;S. Takano;M. Narita;T. Nakai
可溶性细胞角蛋白19片段（CYFRA）和前胃泌素释放肽（ProGRP）是最近被描述的有希望的肺癌肿瘤标志物。同时检测不同程度肾功能衰竭患者血清CYFRA、ProGRP水平，并与癌胚抗原（CEA）、鳞状细胞癌抗原（SCC）、神经元特异性烯醇化酶（NSE）等常规标志物进行比较。除NSE外，所有这些标志物的平均浓度均随肾功能衰竭的严重程度而显著增加。血液透析（HD）后，ProGRP（其分子量与β 2-微球蛋白相当）的平均浓度显著降低。应考虑肾功能衰竭患者肺癌肿瘤标志物的高假阳性率，以避免不必要的诊断程序。
The soluble cytokeratin 19 fragment (CYFRA) and pro-gastrin-releasing peptide (ProGRP) are recently described promising tumor markers for lung cancers. To assess their alterations in renal dysfunction, serum levels of CYFRA and ProGRP were determined together with conventional markers including carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), neuron specific enolase (NSE) in patients with renal failure of varying degrees. The mean concentration of all these markers but NSE significantly increased with the severity of renal failure. After hemodialysis (HD), the mean concentration of ProGRP, the molecular weight of which is comparable to that of 2-microglobulin, was significantly decreased. High false positive rates for tumor markers of lung cancer in patients with renal failure should be considered to avoid unnecessary diagnostic procedures.