Pseudomonas aeruginosa: resistance and therapy.
Pseudomonas aeruginosa: resistance and therapy.
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DOI：
10.1053/srin.2002.34689
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发表时间：
2002-09-01
期刊：
影响因子：
--
通讯作者：
Cunha, Burke A
中科院分区：
文献类型：
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作者：
Cunha, Burke A
铜绿假单胞菌对抗菌药物的耐药性是重要的治疗考虑因素。铜绿假单胞菌的抗生素耐药性可能是染色体或质粒介导的。对铜绿假单胞菌的耐药性也可能受到细胞膜或细胞内环境变化的影响。铜绿假单胞菌主要是一种医院内的微生物，最常见的定植在呼吸道分泌物和尿液中。抗假单胞菌抗生素的选择取决于其固有的体外活性及其耐药性潜力。具有高耐药性潜力的抗铜绿假单胞菌抗生素包括庆大霉素、妥布霉素、环丙沙星、头孢他啶和亚胺培南。具有低耐药性潜力的抗铜绿假单胞菌抗生素包括阿米卡星、哌拉西林、头孢哌酮、头孢吡肟、美罗培南和多粘菌素B。
Pseudomonas aeruginosa resistance to antimicrobials is an important therapeutic consideration. Antibiotic resistance to P. aeruginosa may be chromosomally or plasmid mediated. Resistance to P. aeruginosa may also be affected by changes in the cellular membrane or intracellular environment. P. aeruginosa is primarily a nosocomial organism that most commonly colonizes respiratory secretions and urine. The selection of an antipseudomonal antibiotic depends on its inherent in vitro activity and its resistance potential. Anti-P. aeruginosa antibiotics with a high-resistance potential include gentamicin, tobramycin, ciprofloxacin, ceftazidime, and imipenem. Anti-P. aeruginosa antibiotics with a low-resistance potential include amikacin, piperacillin, cefoperazone, cefepime, meropenem, and polymyxin B.