Harnessing intercellular signals to engineer the soil microbiome.
Harnessing intercellular signals to engineer the soil microbiome.
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DOI：
10.1039/d1np00034a
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发表时间：
2021-12
影响因子：
11.9
通讯作者：
Jack A Connolly;W. Harcombe;M. Smanski;L. Kinkel;E. Takano;R. Breitling
中科院分区：
文献类型：
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作者：
Jack A Connolly;W. Harcombe;M. Smanski;L. Kinkel;E. Takano;R. Breitling
覆盖物：关注2015年至2020年植物和土壤微生物组由来自不同王国的不同生物群落组成，可以深刻影响植物的生长和健康。基于天然产物的细胞间信号控制着微生物组成员之间的重要相互作用，最终调节它们对植物的有益或有害影响。利用这些进化的信号电路来设计微生物组，使其与作物产生有益的相互作用，是一个有吸引力的目标。到目前为止，很少有关于微生物组细胞间信号转导工程的报道，但这篇文章认为，它代表了推进微生物组工程领域的巨大机会。这可以通过选择协同聚生体与信号通路的基因工程相结合来实现，以实现优化的微生物组。
Covering: Focus on 2015 to 2020Plant and soil microbiomes consist of diverse communities of organisms from across kingdoms and can profoundly affect plant growth and health. Natural product-based intercellular signals govern important interactions between microbiome members that ultimately regulate their beneficial or harmful impacts on the plant. Exploiting these evolved signalling circuits to engineer microbiomes towards beneficial interactions with crops is an attractive goal. There are few reports thus far of engineering the intercellular signalling of microbiomes, but this article argues that it represents a tremendous opportunity for advancing the field of microbiome engineering. This could be achieved through the selection of synergistic consortia in combination with genetic engineering of signal pathways to realise an optimised microbiome.