THE DEVELOPMENT OF HUMAN BENIGN PROSTATIC HYPERPLASIA WITH AGE
THE DEVELOPMENT OF HUMAN BENIGN PROSTATIC HYPERPLASIA WITH AGE
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DOI：
10.1016/s0022-5347(17)49698-4
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发表时间：
1984-01-01
影响因子：
6.6
通讯作者：
EWING, LL
中科院分区：
文献类型：
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作者：
BERRY, SJ;COFFEY, DS;EWING, LL
通过合并和分析来自10项独立研究（包含> 1000例前列腺患者）的数据，研究了人类良性前列腺增生的患病率和增长率随年龄的变化。正常前列腺达到20 . ±. 6克。在21-30岁之间的男性中，该重量随着年龄的增长基本保持不变，除非良性前列腺增生发展。病理性良性前列腺增生的患病率在40岁时仅为8%; 50%的男性人群在51-60岁时患有病理性良性前列腺增生。在尸体解剖中被确认为含有良性前列腺增生的前列腺的平均重量为33 . ±. 16克。在70岁以上的男性中，只有4%的前列腺大小超过100 g。前列腺切除术中切除的良性前列腺增生病变的逻辑生长曲线分析表明，良性前列腺增生的生长可能在患者30岁之前就开始了。良性前列腺增生生长的早期阶段（31-50岁之间的男性）的特征在于肿瘤重量的倍增时间为4.5年。在良性前列腺增生生长的中期（51-70岁之间的男性），倍增时间为10年，在70岁以上的患者中增加至> 100年。
The prevalence and growth rate of human benign prostatic hyperplasia with age was studied by combining and analyzing data from 10 independent studies containing > 1000 prostates. The normal prostate reaches 20 .+-. 6 g. in men between 21-30 yr old, and this weight remains essentially constant with increasing age unless benign prostatic hyperplasia develops. The prevalence of pathological benign prostatic hyperplasia is only 8% at the 4th decade; 50% of the male population has pathological benign prostatic hyperplasia when they are 51-60 yr old. The average weight of a prostate that is recognized at autopsy to contain benign prostatic hyperplasia is 33 .+-. 16 g. Only 4% of the prostates in men > 70 yr old reach sizes greater than 100 g. An analysis of a logistic growth curve of benign prostatic hyperplasia lesions removed at prostatectomy indicates that the growth of benign prostatic hyperplasia is initiated probably before the patients is 30 yr old. The early phase of benign prostatic hyperplasia growth (men between 31-50 yr old) is characterized by a doubling time for the tumor weight of 4.5 yr. In the mid phase of benign prostatic hyperplasia growth (men between 51-70 yr old) the doubling time is 10 yr, and increases to > 100 yr in patients beyond 70 yr old.