Urinary 5-aminolevulinic acid (ALA) adjusted by creatinine: A surrogate for plasma ALA?
Urinary 5-aminolevulinic acid (ALA) adjusted by creatinine: A surrogate for plasma ALA?
复制标题
DOI：
10.1097/00043764-199810000-00011
复制
发表时间：
1998-10-01
影响因子：
3.2
通讯作者：
Strickland, PT
中科院分区：
文献类型：
--
作者：
Sithisarankul, P;Schwartz, BS;Strickland, PT
5-氨基乙酰丙酸（ALA）是血红素合成途径中的第一中间底物，也是氨基乙酰丙酸脱氢酶（ALAD，胆色素原合成酶）的底物。由于铅可有效抑制ALAD活性，导致ALA在尿和血液中蓄积，尿ALA（ALAU）已被用作铅暴露或铅早期生物学效应的生物标志物。尿中ALA排泄的个体差异需要使用24小时尿样或通过其他标准化变量（如尿肌酐浓度）调整单个尿样。以往的ALA U浓度研究使用了各种调整方法;然而，很少有人将肌酐调整的ALAU浓度与低（
5-Aminolevulinic acid (ALA) is the first intermediate substrate in the heme synthetic pathway and is the substrate of aminolevulinic acid dehydratase (ALAD, porphobilinogen synthase). Because lead effectively inhibits ALAD activity, resulting in accumulation of ALA in urine and blood, urinary ALA (ALAU) has been used as a biomarker for lead exposure or early biologic effect of lead. Intraindividual variation in urinary excretion of ALA requires the use of 24-hour urine samples or adjustment of single urine samples by other normalizing variables, such as urinary creatinine concentration. Previous studies of ALA U concentration have used various adjustment methods; however, few have compared creatinine-adjusted ALAU concentration with ALA concentration in plasma (ALAP) from subjects with low (