ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES
ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES
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DOI：
10.1136/jnnp.55.3.181
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发表时间：
1992-03-01
影响因子：
11
通讯作者：
LEES, AJ
中科院分区：
文献类型：
--
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
很少有详细的帕金森病的临床病理相关性已发表。本文报告了100例由神经科顾问医师前瞻性诊断为原发性帕金森病的患者的病理结果。其中76人有黑质路易体，在所有这些路易体中，大脑皮层也发现了路易体。在24例无路易体的病例中，诊断包括进行性核上性麻痹、多系统萎缩、阿尔茨海默病、阿尔茨海默型病理和基底节血管疾病。回顾性应用推荐的诊断标准将诊断准确率提高到82%。这些观察结果对目前帕金森病作为一种独特的病态实体的概念提出了质疑。
Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive supranuclear palsy, multiple system atrophy, Alzheimer's disease, Alzheimer-type pathology, and basal ganglia vascular disease. The retrospective application of recommended diagnostic criteria improved the diagnostic accuracy to 82%. These observations call into question current concepts of Parkinson's disease as a single distinct morbid entity.