POTENTIAL MAGNITUDE OF THE MISCLASSIFICATION OF A POPULATIONS TRACE-ELEMENT STATUS DUE TO INFECTION - EXAMPLE FROM A SURVEY OF YOUNG PERUVIAN CHILDREN
POTENTIAL MAGNITUDE OF THE MISCLASSIFICATION OF A POPULATIONS TRACE-ELEMENT STATUS DUE TO INFECTION - EXAMPLE FROM A SURVEY OF YOUNG PERUVIAN CHILDREN
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DOI：
10.1093/ajcn/58.4.549
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发表时间：
1993-10-01
影响因子：
7.1
通讯作者：
LONNERDAL, B
中科院分区：
文献类型：
--
作者：
BROWN, KH;LANATA, CF;LONNERDAL, B
为了研究并发感染对基于人群的微量元素状态评估的影响，我们收集了153名11-19个月秘鲁儿童的临床体征和实验室感染指标的数据，这些数据是在获得血液进行血清锌、铜和铁蛋白分析时获得的。52名（34.7%）儿童报告了一些感染体征，43名（28.3%）儿童C反应蛋白浓度升高或白细胞增多。有任何感染迹象的儿童平均（+/-SD）血清锌浓度略低（7.0 +/- 2.3 vs 7.5 +/- 2.0 mumol/L，P = 0.16）和血清铜显著升高（24.7 +/- 4.7 vs 22.7 +/- 4.2 mumol/L，P = 0.006）和血清铁蛋白浓度（10.0 +/- 12.9 vs 3.9 +/- 4.4 mug/L，P < 0.001）。感染导致低铜状态的比率被低估了1个百分点，低铁状态被低估了12个百分点。因此，并发感染的影响程度不同，可能因营养、人群营养状况以及感染的流行率和严重程度而异。
To examine the effects of concurrent infection on population-based assessment of trace element status, we collected data on clinical signs and laboratory indicators of infection when obtaining blood for serum zinc, copper, and ferritin analyses in 153 Peruvian children aged 11-19 mo. Fifty-two (34.7%) of the children had some reported sign of infection and 43 (28.3%) had elevated C-reactive protein concentrations or leukocytosis. Children with any evidence of infection had marginally lower mean (+/-SD) serum zinc concentrations (7.0 +/- 2.3 vs 7.5 +/- 2.0 mumol/L, P = 0.16) and significantly greater serum copper (24.7 +/- 4.7 vs 22.7 +/- 4.2 mumol/L, P = 0.006) and serum ferritin concentrations (10.0 +/- 12.9 vs 3.9 +/- 4.4 mug/L, P < 0.001) than did those without infections. Infection caused an underestimation in the rate of low copper status by 1 percentage point and low iron status by 12 percentage points. Thus, the effect of concurrent infections is of variable magnitude and may differ by nutrient, nutritional status of the population, and prevalence and severity of infections.