Bipolar mood cycles associated with lunar entrainment of a circadian rhythm
Bipolar mood cycles associated with lunar entrainment of a circadian rhythm
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DOI：
10.1038/s41398-018-0203-x
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发表时间：
2018-08-13
影响因子：
6.8
通讯作者：
Wehr, Thomas A.
中科院分区：
文献类型：
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作者：
Wehr, Thomas A.
在双相情感障碍中，抑郁症和躁狂症的发作与睡眠中的剧烈干扰有关，实验表明这可能有助于发作的发病机制。最近的一项研究发现，18名患者的躁狂抑郁周期与两周一次的月球潮汐振幅同步振荡，这为睡眠障碍的原因提供了线索。对其中一名患者的睡眠-觉醒周期的分析表明，他的情绪周期是在昼夜节律（通常被带到黎明并控制每日觉醒的开始）被带到每隔12.4小时的潮汐周期的24.8小时循环时出现的。这一发现为全面描述情绪周期的发病机制和病理生理学提供了基础。
In bipolar disorder, episodes of depression and mania are associated with dramatic disturbances in sleep, which experiments show are likely to contribute to the pathogenesis of the episodes. A recent finding that 18 patients' manic-depressive cycles oscillated in synchrony with biweekly surges in amplitude of the moon's tides provided a clue to the cause of the sleep-disturbances. Analyses of one of the patients' sleep-wake cycles suggest that his mood cycles arose when a circadian rhythm that normally is entrained to dawn and controls the daily onset of wakefulness became entrained instead to 24.8-h recurrences of every second 12.4-h tidal cycle. The finding provides the basis for a comprehensive description of the pathogenesis and pathophysiology of the mood cycle.