Prevalence of clinically important histology in small adenomas
Prevalence of clinically important histology in small adenomas
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DOI：
10.1016/j.cgh.2005.12.021
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发表时间：
2006-03-01
影响因子：
12.6
通讯作者：
Fiarman, GS
中科院分区：
文献类型：
--
作者：
Butterly, LF;Chase, MP;Fiarman, GS
背景与目的：考虑到计算机断层扫描结肠镜的出现，小息肉的晚期组织学流行率已成为优化结直肠癌筛查策略的关键问题。我们评估了晚期组织学在小型和微型腺瘤中的患病率，以阐明其在恶性潜能方面的临床重要性。方法：回顾性分析3291例无症状患者的结肠镜检查资料，这些患者在结肠镜检查前几周通过柔性乙状结肠镜检查发现有腺瘤或有结直肠癌家族史。所有息肉均经内镜切除并送病理检查。具有高级组织学的标本经二读确认。结果：在3291例结肠镜检查中，1235例结肠镜检查共产生1933例小或小型腺瘤性息肉。10.1%的小腺瘤（5-10 mm）和1.7%的小腺瘤(
Background & Aims: The prevalence of advanced histology in small polyps has become a crucial issue in optimizing colorectal cancer screening strategies, especially in view of the advent of computed tomography colonography. We evaluated the prevalence of advanced histology in small and diminutive adenomas to clarify their clinical importance in terms of malignant potential. Methods: Data were reviewed retrospectively from 3291 colonoscopies performed on asymptomatic patients found to have an adenoma on screening with flexible sigmoidoscopy a few weeks before the colonoscopy or who had a family history of colorectal cancer. All polyps were excised endoscopically and sent for pathology testing. Specimens with advanced histology were confirmed by a second reading. Results: Of the 3291 colonoscopies performed, 1235 colonoscopies yielded a total of 1933 small or diminutive adenomatous polyps. Advanced histology including carcinoma was found in 10.1% of small (5-10 mm) adenomas and in 1.7% of diminutive adenomas (