Stereospecific Decarboxylative Benzylation of Enolates: Development and Mechanistic Insight
Stereospecific Decarboxylative Benzylation of Enolates: Development and Mechanistic Insight
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DOI：
10.1021/acs.orglett.8b00169
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发表时间：
2018-04-06
期刊：
影响因子：
5.2
通讯作者：
Tunge, Jon A.
中科院分区：
文献类型：
--
作者：
Li, Tian-Ren;Maliszewski, Mary L.;Tunge, Jon A.
研究了由仲苯醇衍生的烯醇碳酸酯与二芳基甲基亲电试剂的钯催化脱羧偶联反应。这种方法允许通过高效和高度立体特异性的偶联产生多种β -二芳基酮。此外，对耦合的详细机理分析表明，该反应是反应物之间分子内脱羧的罕见例子。
A palladium-catalyzed decarboxylative coupling of enol carbonates with diarylmethyl electrophiles that are derived from secondary benzylic alcohols has been developed. This method allows the generation of a variety of beta-diaryl ketones through an efficient and highly stereospecific coupling. In addition, detailed mechanistic insight into the coupling suggests that the reaction is a rare example of an intramolecular decarboxylative between reactants.