High relative frequency of oral squamous cell carcinoma in Yemen: Qat and tobacco chewing as its aetiological background
High relative frequency of oral squamous cell carcinoma in Yemen: Qat and tobacco chewing as its aetiological background
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DOI：
10.1080/09603120701254813
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Saku, Takashi
中科院分区：
文献类型：
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作者：
Sawair, Faleh A.;Al-Mutwakel, Ammar;Saku, Takashi
为了研究咀嚼咖特与口腔癌发生的关系，在咀嚼咖特最盛行的也门，对全身癌症中口腔癌的发生率以及患者的烟草消费和咀嚼咖特史进行了调查。对萨那大学Al-Thawra医院2004年手术病理档案中列出的所有原发性恶性肿瘤进行了分析，并检查了患者的吸烟史和咀嚼咖特史。共提取原发性恶性肿瘤649例（男性348例，占53.6%；女性301例，占46.4%）。口腔癌是男性 (17.2%) 和女性 (19.6%) 中最常见的身体癌症。鳞状细胞癌（SCC）是最常见的口腔癌（84%），舌（42%）、牙龈（23%）和颊粘膜（20%）是最常见的部位。在119名口腔癌患者中，92名患者（77.3%）获得了咀嚼习惯和吸烟的信息。其中有 70 名咀嚼烟草者（76.1%）、55 名咀嚼咖特（59.8%）和 22 名吸烟者（23.9%）。 48 例（52.2%）同时咀嚼烟草和咖特。本次调查首次披露，口腔鳞状细胞癌是也门该研究地区最常见的癌症，口腔鳞状细胞癌相对发生率较高可能与咀嚼烟草和咖特的习惯有关。
To study the association of qat chewing with the occurrence of oral cancer, the frequency of oral cancer among whole body cancers and the patients' histories of tobacco consumption and qat chewing were examined in Yemen where qat chewing has been most popular. All primary malignant tumors listed in the surgical pathology files at Al-Thawra Hospital, University of Sana'a, in the year 2004 were analyzed, and the patients' histories of tobacco consumption and qat chewing were examined. A total of 649 cases of primary malignant tumors (348, 53.6% males and 301, 46.4% females) were extracted. Oral cancer was the most frequent body cancer in both males (17.2%) and females (19.6%). Squamous cell carcinoma (SCC) was the most frequent oral cancer (84%), and the tongue (42%), gingiva (23%) and buccal mucosa (20%) were the most common sites. Among the 119 patients with oral cancer, information on chewing habits and smoking was obtained in 92 patients (77.3%). There were 70 tobacco chewers (76.1%), 55 qat chewers (59.8%), and 22 smokers (23.9%). Simultaneous chewing of tobacco and qat was found in 48 cases (52.2%). The present survey has disclosed for the first time that oral SCC is the most frequent cancer in this study area in Yemen, and that the high relative frequency of oral SCC may be related to the habits of chewing tobacco and qat.