What happens to cardiovascular system behind the undetectable level of HIV viremia?
What happens to cardiovascular system behind the undetectable level of HIV viremia?
复制标题
DOI：
10.1186/s12981-016-0105-z
复制
发表时间：
2016
影响因子：
2.2
通讯作者：
Vullo V
中科院分区：
文献类型：
--
作者：
d'Ettorre G;Ceccarelli G;Pavone P;Vittozzi P;De Girolamo G;Schietroma I;Serafino S;Giustini N;Vullo V
尽管联合抗逆转录病毒疗法改善了艾滋病毒感染者的生存时间和生活质量，但与一般人群相比，这些患者的生存率总是下降。这是包括心血管疾病在内的非传染性疾病的后果。事实上，大量研究表明，即使在接受cART的HIV患者中，冠状动脉粥样硬化疾病、心肌梗死的风险也会增加。在HIV感染患者中，有几个因素可能导致心血管问题的发病机制：生活方式、代谢参数、遗传易感性、病毒因素、免疫激活、慢性炎症和抗逆转录病毒治疗的副作用。同样的因素也可能导致这些患者的临床管理复杂化。因此，在HIV感染人群中治疗这些非传染性疾病是医生面临的一个新挑战。本文综述了HIV病毒血症受抑制患者非艾滋病相关心血管疾病的新认识。
Despite the combined antiretroviral therapy has improved the length and quality of life of HIV infected patients, the survival of these patients is always decreased compared with the general population. This is the consequence of non-infectious illnesses including cardio vascular diseases. In fact large studies have indicated an increased risk of coronary atherosclerotic disease, myocardial infarction even in HIV patients on cART. In HIV infected patients several factors may contribute to the pathogenesis of cardiovascular problems: life-style, metabolic parameters, genetic predisposition, viral factors, immune activation, chronic inflammation and side effects of antiretroviral therapy. The same factors may also contribute to complicate the clinical management of these patients. Therefore, treatment of these non-infectious illnesses in HIV infected population is an emerging challenge for physicians. The purpose of this review is to focus on the new insights in non AIDS-related cardiovascular diseases in patients with suppressed HIV viremia.