Emerging roles of nucleotide metabolism in cancer.
Emerging roles of nucleotide metabolism in cancer.
复制标题
核苷酸代谢在癌症中的新作用。
DOI：
10.1016/j.trecan.2023.04.008
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发表时间：
2023
期刊：
影响因子：
18.4
通讯作者：
McBrayer,SamuelK
中科院分区：
文献类型：
--
作者：
Shi,DianaD;Savani,MilanR;Abdullah,KalilG;McBrayer,SamuelK
核苷酸是多种合成代谢途径的底物，尤其是 DNA 和 RNA 合成。自从 20 世纪 50 年代核苷酸合成抑制剂开始用于癌症治疗以来，我们对核苷酸在肿瘤细胞中如何发挥作用的理解不断发展，促使人们重新燃起对靶向核苷酸代谢用于癌症治疗的兴趣。在这篇综述中，我们讨论了挑战核苷酸只是基因组和转录组构建模块这一观点的最新进展，并强调了这些代谢物支持肿瘤细胞中致癌信号、应激抵抗和能量稳态的方式。这些发现表明癌症中异常核苷酸代谢维持着丰富的过程网络，并揭示了新的治疗机会。
Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the 1950s, our understanding of how nucleotides function in tumor cells has evolved, prompting a resurgence of interest in targeting nucleotide metabolism for cancer therapy. In this review, we discuss recent advances that challenge the idea that nucleotides are mere building blocks for the genome and transcriptome and highlight ways that these metabolites support oncogenic signaling, stress resistance, and energy homeostasis in tumor cells. These findings point to a rich network of processes sustained by aberrant nucleotide metabolism in cancer and reveal new therapeutic opportunities.