Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella
Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella
复制标题
冬青根中的十一种新三萜苷
DOI：
10.1002/cbdv.201900202
复制
发表时间：
2019-07-01
影响因子：
2.9
通讯作者：
Ye, Wen-Cai
中科院分区：
文献类型：
--
作者：
Huang, Xiao-Jun;Wen, Si;Ye, Wen-Cai
从冬青根中分离得到9个新的熊果烷型三萜苷(1-9)和2个新齐墩果烷型三萜苷(10和11)，其中包括6个稀有的硫酸化三萜苷。通过综合光谱分析和化学方法确定了它们的结构。其中，asprelloside B(2)和asprelloside C(3)是含有稀有的3，4-O-二磺酸基吡喃糖基的三萜苷的第一个例子。分离得到的皂苷对呼吸道合胞病毒(RSV)和脂多糖诱导的Raw264.7巨噬细胞一氧化氮的产生均无明显的抑制作用。
Asprellosides A-K, nine new ursane-type triterpenoid glycosides (1-9), and two new oleanane-type triterpenoid glycosides (10 and 11), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella. Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B (2) and asprelloside C (3) are the first examples of triterpenoid glycosides bearing a rare 3,4-O-disulfo-xylopyranosyl residue. All the saponins isolated showed no significant effects against respiratory syncytial virus (RSV) and lipopolysaccharide-induced nitric oxide production in Raw264.7 macrophages.