Molecular definition of the identity and activation of natural killer cells.
Molecular definition of the identity and activation of natural killer cells.
复制标题
作者：
利用免疫基因组计划的全基因组微阵列数据集，我们证明NK细胞和T细胞之间的转录关系比任何其他白细胞更密切，其特征是它们表达类似的信号功能。虽然已知静止NK细胞与细胞毒性CD8+ T细胞共享少数基因的表达，但转录组范围的分析表明，这种共性延伸到数百个基因，其中许多基因具有未知的功能。相对于细胞毒性CD8+ T细胞，NK细胞对病毒感染的反应受到抑制，部分原因是它们的“预启动”状态。总的来说，这些数据通过描述NK细胞在不同状态下的基因表达的全基因组库，为NK细胞身份和功能的已知和新的分子方面提供了全球背景。
Using whole-genome microarray datasets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK and T cells than any other leukocytes, distinguished by their expression of similar signaling functions. While resting NK cells were known to share expression of a few genes with cytotoxic CD8+ T cells, transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many with unknown functions. The NK cell response to viral infection is dampened relative to cytotoxic CD8+ T cells, in part due to their “pre-primed” state. Collectively, the data provide global context for known and novel molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.