Impact of aging immune system on neurodegeneration and potential immunotherapies
Impact of aging immune system on neurodegeneration and potential immunotherapies
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衰老免疫系统对神经退行性变和潜在免疫疗法的影响
DOI：
10.1016/j.pneurobio.2017.07.006
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发表时间：
2017-10-01
影响因子：
6.7
通讯作者：
Zhao, Yong
中科院分区：
文献类型：
--
作者：
Liang, Zhanfeng;Zhao, Yang;Zhao, Yong
衰老过程中神经系统和免疫系统之间的相互作用是一个非常感兴趣的领域，但许多方面仍不清楚。这不仅是由于衰老过程的复杂性，而且是由于神经系统和免疫系统之间的相互依赖性和相互因果关系。大脑的老化会导致全身系统性老化，包括免疫系统的老化相关变化。反过来，免疫系统老化，特别是由胸腺退化引发的免疫衰老和T细胞老化，是老年人慢性炎症（称为炎症）的来源，可能以相互作用的方式诱导脑老化和记忆丧失。因此，包括炎症调节、疫苗接种、细胞免疫疗法和“保护性自身免疫”在内的免疫疗法提供了恢复神经炎性疾病和修复脑损伤的有希望的方法。在这篇综述中，我们总结了最近的发现，将衰老的免疫系统与神经退行性疾病的发展联系起来。此外，我们还讨论了潜在的年轻化策略，重点是针对衰老的免疫系统，以防止衰老过程中的急性脑损伤和慢性神经退行性变。(C)2017爱思唯尔有限公司版权所有
The interaction between the nervous and immune systems during aging is an area of avid interest, but many aspects remain unclear. This is due, not only to the complexity of the aging process, but also to a mutual dependency and reciprocal causation of alterations and diseases between both the nervous and immune systems. Aging of the brain drives whole body systemic aging, including aging-related changes of the immune system. In turn, the immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution that are sources of chronic inflammation in the elderly (termed inflammaging), potentially induces brain aging and memory loss in a reciprocal manner. Therefore, immunotherapeutics including modulation of inflammation, vaccination, cellular immune therapies and "protective autoimmunity" provide promising approaches to rejuvenate neuroinflammatory disorders and repair brain injury. In this review, we summarize recent discoveries linking the aging immune system with the development of neurodegeneration. Additionally, we discuss potential rejuvenation strategies, focusing aimed at targeting the aging immune system in an effort to prevent acute brain injury and chronic neurodegeneration during aging. (C) 2017 Elsevier Ltd. All rights reserved.