Type 2 Diabetes in Octogenarians Is Associated with Decreased Low Molecular Weight Adiponectin
Type 2 Diabetes in Octogenarians Is Associated with Decreased Low Molecular Weight Adiponectin
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DOI：
10.1159/000316575
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发表时间：
2011-01-01
期刊：
影响因子：
3.5
通讯作者：
Fischer, Sabine
中科院分区：
文献类型：
--
作者：
Graessler, Juergen;Gruber, Matthias;Fischer, Sabine
背景资料：脂联素以三种不同的多聚体亚型在血液中循环，其中高分子量形式（HMW）被认为介导胰岛素敏感性。我们研究了脂联素寡聚体分布是否与无代谢综合征特征的老年人的衰老和2型糖尿病（T2 D）相关。研究方法：该研究包括154名老年人（58名男性，96名女性），24名血糖正常的中年对照（11名男性，13名女性;平均年龄44岁）和33名中年T2 D患者（14名男性，19名女性;平均年龄55岁）。根据口服葡萄糖耐量试验，62名老年人正常，63名老年人糖耐量受损，29名老年人新发现T2 D。血清脂联素多聚体异构体测定过夜后，通过酶联免疫吸附试验。结果如下：与血糖正常的中年对照组相比，男性血糖正常的老年人显示出显著较高的总脂联素和所有脂联素亚型。女性也是如此，但低分子量（LMW）脂联素除外，其在男性中没有统计学意义上更高。与中年T2 D患者相比，男性和女性T2 D老年患者的总脂联素、HMW脂联素和中分子量（MMW）脂联素水平显著更高，但LMW脂联素水平不高。女性，而不是男性，糖尿病患者显示显着低于总脂联素比血糖正常的糖尿病患者。与血糖正常的老年人相比，男性和女性T2 D老年人的特征是LMW脂联素显著降低。在男性和女性肥胖者中，总脂联素和所有多聚体亚型与HDL胆固醇直接相关。低分子量脂联素与2小时口服葡萄糖耐量试验的血糖水平呈负相关。结论：与相应的中年对照组相比，糖尿病正常或2型糖尿病的老年人血清总脂联素及其HMW和MMW亚型水平显著升高。在无代谢综合征的男性和女性糖尿病患者中，T2 D与低LMW脂联素相关，而HMW和MMW亚型无统计学差异。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Adiponectin circulates in the blood in three different multimer isoforms, of which the high molecular weight form (HMW) is presumed to mediate insulin sensitivity. We examined whether adiponectin oligomer distribution is associated with aging and type 2 diabetes (T2D) in octogenarians without characteristic features of metabolic syndrome. Methods: The study included 154 octogenarians (58 men, 96 women), 24 normoglycemic middle-aged controls (11 men, 13 women; mean age 44 years), and 33 middle-aged individuals (14 men, 19 women; mean age 55 years) with T2D. Based on oral glucose tolerance test 62 octogenarians had normal, 63 impaired glucose tolerance, and 29 octogenarians had newly detected T2D. Serum adiponectin multimer isoforms were measured after overnight fast by enzyme-linked immunosorbent assays. Results: Compared to the normoglycemic middle-aged control group, male normoglycemic octogenarians revealed significantly higher total adiponectin and all adiponectin isoforms. The same was true for females with the exception of low molecular weight (LMW) adiponectin, which was not statistically higher in octogenarians. Male and female octogenarians with T2D had significantly higher levels of total, HMW, and middle molecular weight (MMW) adiponectin, but not LMW adiponectin, than middle-aged individuals with T2D. Female, but not male, octogenarians revealed significantly lower total adiponectin than normoglycemic octogenarians. Compared with normoglycemic octogenarians, male and female octogenarians with T2D were characterized by significantly lower LMW adiponectin. In male and female octogenarians, total adiponectin and all multimer isoforms were directly correlated with HDL cholesterol. LMW adiponectin in octogenarians of both sexes was inversely correlated with glucose level at 2-hour oral glucose tolerance test. Conclusions: Serum levels of total adiponectin as well as its HMW and MMW isoforms were significantly higher in octogenarians with normoglycemia or T2D than in corresponding middle-aged control groups. In male and female octogenarians without metabolic syndrome, T2D was associated with lower LMW adiponectin, while the HMW and MMW isoforms were not statistically different. Copyright (C) 2010 S. Karger AG, Basel