HIGH-FREQUENCY OF X-Y CHROMOSOME DISSOCIATION IN PRIMARY SPERMATOCYTES OF F1 HYBRIDS BETWEEN JAPANESE WILD MICE (MUS-MUSCULUS-MOLOSSINUS) AND INBRED LABORATORY MICE
HIGH-FREQUENCY OF X-Y CHROMOSOME DISSOCIATION IN PRIMARY SPERMATOCYTES OF F1 HYBRIDS BETWEEN JAPANESE WILD MICE (MUS-MUSCULUS-MOLOSSINUS) AND INBRED LABORATORY MICE
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DOI：
10.1159/000131565
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
MORIWAKI, K
中科院分区：
文献类型：
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作者：
IMAI, HT;MATSUDA, Y;MORIWAKI, K
在日本野鼠(M.molossinus)与近交系实验鼠(BALB/c和B10.BR)的杂交中，约有70%的精母细胞在第一次减数分裂中期X、Y染色体早熟分离，而近交系实验鼠仅为8.9%，野生鼠为21.1%。X-Y解离至少在终变期早期开始，并持续到中期I(MI)。杂交小鼠(10.1%)和BALB/c小鼠(10.6%)的一些常染色体也发生了早熟分离，但X-Y染色体与常染色体分离没有明显的相关性。在含有野生黄曲霉Y染色体的B10或B6同源系中，随着回交世代的增加，早熟X-Y解离率有明显下降的趋势。发现的X-Y分离是由基因控制的，可能受多个基因控制；这些基因位于常染色体上，只有当它们是杂合体时才活跃；性染色体的频繁分离既不影响男性生育能力，也不会导致X和Y染色体不分离，尽管它显著减轻了睾丸重量。
In the hybrids between Japanese wild mice (M. m. molossinus) and inbred laboratory mice (BALB/c and B10.BR, which were probably derived from M. m. domesticus), the X and Y chromosomes dissociated precociously at the 1st meiotic metaphase in some 70% of spermatocytes; that percentage was only 8.9% in inbred laboratory mice and 21.1% in wild mice. X-Y dissociation began at least at early diakinesis and continued during metaphase I (MI). Some autosomes of the hybrid (10.1%) and BALB/c (10.6%) mice also dissociated precociously, but there was no distinctive correlation between X-Y and autosomal dissociation. In B10 or B6 congenic lines with a Y chromosome from wild M. m. molossinus, there was an apparent tendency for the percentage of precocious X-Y dissociation to decrease with an increasing number of backcross generations. The X-Y dissociation found is genetically controlled, perhaps by multiple genes; these genes are located on autosomes and are active only when they are heterozygous; and the frequent dissociation of the sex chromosomes neither affects male fertility nor induces non-disjunction of the X and Y chromosomes, though it significantly reduces testes weight.