An Open-source Computational Model of Neurostimulation of the Spinal Pudendo-Vesical Reflex for the Recovery of Bladder Control After Spinal Cord Injury.
An Open-source Computational Model of Neurostimulation of the Spinal Pudendo-Vesical Reflex for the Recovery of Bladder Control After Spinal Cord Injury.
复制标题
用于脊髓损伤后膀胱控制恢复的脊髓阴部膀胱反射神经刺激的开源计算模型。
DOI：
10.1109/embc48229.2022.9871195
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Capogrosso,Marco
中科院分区：
文献类型：
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作者：
Fang,Xiaoqi;Collins,Scott;Nanivadekar,AmeyaC;Jantz,Maria;Gaunt,RobertA;Capogrosso,Marco
脊髓刺激（SCS）可用于在脊髓损伤后恢复膀胱的控制，但仍需要大量开发来适应膀胱功能。可以利用计算模型来加速这些工作，从而实现刺激参数的计算机优化。然而，没有任何脊髓阴部膀胱反射模型可以模拟刺激幅度对神经元募集的影响。这种限制阻碍了对不同刺激配置的膀胱压力变化的准确预测。在这里，我们实现了阴部膀胱反射的开源真实尖峰神经网络模型，能够探索刺激幅度和频率对膀胱压力变化的影响。我们使用 o2S2PARC 平台设计了膀胱反射电路与 NEURON 的并行实现。我们的模型成功地再现和扩展了先前的研究，在等容实验中产生低刺激频率（10 Hz）下膀胱压力的降低和高刺激频率（≥33 Hz）下的兴奋。然后，我们模拟了选择性较差的脊髓刺激的常见情况，探讨了混合神经募集的效果。我们发现，无论刺激特异性如何，阴部神经轴突的大量募集对于维持这种双模式行为是必要的。我们的框架是完全开源的，可用于模拟任何类型的轴突刺激，例如 SCS 和周围神经刺激。
Spinal cord stimulation (SCS) could be used to restore control of the bladder after spinal cord injury, but substantial development is still required to tailor this technology for bladder function. Computational models could be utilized to accelerate these efforts enabling in-silico optimization of stimulation parameters. However, no model of the spinal pudendo-vesical reflex can simulate the effect of stimulation amplitude on neuron recruitment. This limitation hinders accurate prediction of bladder pressure changes for different stimulation configurations. Here., we implemented an open-source realistic spiking neural network model of the pudendo-vesical reflex enabling exploration of the impact of stimulation amplitude and frequency on bladder pressure changes. We used the o2S2PARC platform to design a parallel implementation of the bladder reflex circuits with NEURON. Our model successfully reproduced and expanded previous studies., producing a decrease in bladder pressure at low stimulation frequency (10 Hz) and excitation at high stimulation frequency (≥33 Hz) in isovolumetric experiments. We then explored the effect of mixed nerve recruitment., simulating a common case of poorly selective spinal cord stimulation. We found that high recruitments of pudendal nerve axons are necessary to maintain this bi-modal behavior., regardless of stimulation specificity. Our framework is fully open-source and can be used to simulate any type of axon stimulations such as SCS and peripheral nerve stimulation.